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    Mtus1 microtubule associated scaffold protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306487, updated on 3-Dec-2024

    Summary

    Symbol
    Mtus1provided by RGD
    Full Name
    microtubule associated scaffold protein 1provided by RGD
    Primary source
    RGD:631381
    See related
    EnsemblRapid:ENSRNOG00000010748 AllianceGenome:RGD:631381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ATIP4; Mtsg1; Atip3b
    Summary
    Predicted to enable microtubule binding activity. Involved in cellular response to angiotensin. Predicted to be located in microtubule cytoskeleton and nucleolus. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 617.5), Adrenal (RPKM 314.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mtus1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57905991..58051466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51202497..51347794)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54240892..54386131)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pericentriolar material 1 Neighboring gene fibrinogen-like 1 Neighboring gene uncharacterized LOC103693968 Neighboring gene uncharacterized LOC120097427 Neighboring gene uncharacterized LOC120097428 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene elongin B, pseduogene 1 Neighboring gene solute carrier family 7 member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    microtubule-associated tumor suppressor 1 homolog
    Names
    angiotensin-II type 2 receptor-interacting protein
    growth factor inhibitor
    microtubule associated tumor suppressor 1
    mitochondrial tumor suppressor 1
    transcription factor MTSG1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395000.1NP_001381929.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      B1A2U8
      Related
      ENSRNOP00000069962.1, ENSRNOT00000079006.3
      Conserved Domains (1) summary
      TIGR02168
      Location:8351154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_178093.2NP_835194.2  microtubule-associated tumor suppressor 1 homolog isoform 2

      See identical proteins and their annotated locations for NP_835194.2

      Status: VALIDATED

      Source sequence(s)
      BC072537
      UniProtKB/Swiss-Prot
      Q6IMY1, Q6XUU5, Q80Z99
      UniProtKB/TrEMBL
      A6JPU4, I7GGY1
      Related
      ENSRNOP00000030995.2, ENSRNOT00000037685.7
      Conserved Domains (1) summary
      TIGR02168
      Location:66385
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      57905991..58051466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253181.5XP_006253243.1  microtubule-associated tumor suppressor 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006253243.1

      UniProtKB/TrEMBL
      B1A2U8
      Conserved Domains (1) summary
      TIGR02168
      Location:8351154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. XM_063275428.1XP_063131498.1  microtubule-associated tumor suppressor 1 homolog isoform X1

      UniProtKB/TrEMBL
      B1A2U8
    3. XM_017600120.3XP_017455609.1  microtubule-associated tumor suppressor 1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZY91, I7GGY1
      Related
      ENSRNOP00000102205.1, ENSRNOT00000153250.1
    4. XM_006253182.5XP_006253244.1  microtubule-associated tumor suppressor 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006253244.1

      UniProtKB/TrEMBL
      D2XRB8
      Related
      ENSRNOP00000070944.1, ENSRNOT00000090266.3
      Conserved Domains (2) summary
      pfam09755
      Location:193460
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)
      cl19219
      Location:330406
      DUF342; Protein of unknown function (DUF342)
    5. XM_017600121.3XP_017455610.1  microtubule-associated tumor suppressor 1 homolog isoform X4

      UniProtKB/TrEMBL
      I7GGY1
    6. XM_017600122.3XP_017455611.1  microtubule-associated tumor suppressor 1 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8L2QL23, I7GGY1
    7. XM_039094527.2XP_038950455.1  microtubule-associated tumor suppressor 1 homolog isoform X6

      Related
      ENSRNOP00000084500.2, ENSRNOT00000102597.2
      Conserved Domains (1) summary
      TIGR02168
      Location:14291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_010058295.1 RNA Sequence