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    diras1a DIRAS family, GTP-binding RAS-like 1a [ Danio rerio (zebrafish) ]

    Gene ID: 327577, updated on 4-Jan-2025

    Summary

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    Official Symbol
    diras1aprovided by ZNC
    Official Full Name
    DIRAS family, GTP-binding RAS-like 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5788
    See related
    Ensembl:ENSDARG00000028066 AllianceGenome:ZFIN:ZDB-GENE-030131-5788
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    diras1; fi18d11; zgc:55360; wu:fi18d11
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within neuron development and trigeminal ganglion development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and otic vesicle. Orthologous to human DIRAS1 (DIRAS family GTPase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See diras1a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (7324819..7341570)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (7314980..7331731)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch73-238c9.1 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene IFI30 lysosomal thiol reductase b Neighboring gene vitellogenin 3, phosvitinless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway. Yeh CW, et al. Mol Neurobiol, 2016 Dec. PMID 26635085
    2. Genome editing reveals reproductive and developmental dependencies on specific types of vitellogenin in zebrafish (Danio rerio). Yilmaz O, et al. Mol Reprod Dev, 2019 Sep. PMID 31380595
    3. Multiple vitellogenins in zebrafish (Danio rerio): quantitative inventory of genes, transcripts and proteins, and relation to egg quality. Yilmaz O, et al. Fish Physiol Biochem, 2018 Dec. PMID 29882000
    4. Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio). Yilmaz O, et al. Sci Rep, 2023 Nov 1. PMID 37914813, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. diras1a and diras1b enhanced Rac1 activity.
      Title: Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trigeminal ganglion development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within trigeminal ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein Di-Ras1a
    Names
    DIRAS family, GTP-binding RAS-like 1
    small GTP-binding tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199831.1 → NP_956125.1  GTP-binding protein Di-Ras1a

      See identical proteins and their annotated locations for NP_956125.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044147
      UniProtKB/TrEMBL
      Q803Y2
      Related
      ENSDARP00000038292.2, ENSDART00000031937.4
      Conserved Domains (2) summary
      smart00173
      Location:20 → 171
      RAS; Ras subfamily of RAS small GTPases
      cl21455
      Location:7 → 169
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      7324819..7341570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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