cdk8 cyclin dependent kinase 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdk8provided by ZNC
Official Full Name: cyclin dependent kinase 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-030903-2
See related: Ensembl:ENSDARG00000016496 AllianceGenome:ZFIN:ZDB-GENE-030903-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk95h11
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21514286..21539344)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21369103..21394170)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hdac1 regulates differentiation of liver progenitor cells into hepatocytes via Sox9b and differentiation of LPCs into biliary epithelial cells via Cdk8, Fbxw7, and Notch3 in zebrafish with severe hepatocyte loss.
Title: Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8.
Cloning, sequencing and developmental expression pattern of cyclin-dependent kinase 8.
Title: Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase 8

Names: cell division protein kinase 8; mediator complex subunit cdk8; mediator of RNA polymerase II transcription subunit cdk8

NP_919389.2

EC 2.7.11.22

EC 2.7.11.23

XP_005162735.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194408.2 → NP_919389.2 cyclin-dependent kinase 8

Status: VALIDATED

Source sequence(s)

AL929009, EH438438, EH464385

UniProtKB/Swiss-Prot

Q8JH47

UniProtKB/TrEMBL

A0A8M1PB09, A8E4S2

Related

ENSDARP00000022588.6, ENSDART00000007066.7

Conserved Domains (1) summary

cd07868
Location:3 → 335

STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

21514286..21539344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162678.5 → XP_005162735.1 cyclin-dependent kinase 8 isoform X1

UniProtKB/Swiss-Prot

Q8JH47

UniProtKB/TrEMBL

A0A8M2B9W5

Conserved Domains (1) summary

cd07868
Location:3 → 335

STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8