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    Commd5 COMM domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245974, updated on 9-Dec-2024

    Summary

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    Symbol
    Commd5provided by RGD
    Full Name
    COMM domain containing 5provided by RGD
    Primary source
    RGD:621468
    See related
    EnsemblRapid:ENSRNOG00000004484 AllianceGenome:RGD:621468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hcarg
    Summary
    Involved in positive regulation of cell growth; positive regulation of epithelial cell differentiation; and proximal tubule morphogenesis. Located in nucleus. Orthologous to human COMMD5 (COMM domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 96.6), Kidney (RPKM 75.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Commd5 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110502492..110503916)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108621766..108623616)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117963213..117965010)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 251 Neighboring gene U1 spliceosomal RNA Neighboring gene zinc finger protein 7 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HCaRG increases renal cell migration by a TGF-alpha autocrine loop mechanism. El Hader C, et al. Am J Physiol Renal Physiol, 2005 Dec. PMID 16033922
    2. HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest. Devlin AM, et al. Am J Physiol Renal Physiol, 2003 Apr. PMID 12620924
    3. Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair. Matsuda H, et al. J Nephrol, 2014 Aug. PMID 24515317, Free PMC Article
    4. Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Chen BL, et al. Oncol Rep, 2008 Nov. PMID 18949406
    5. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. Solban N, et al. J Biol Chem, 2000 Oct 13. PMID 10918053

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
      Title: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression.
    2. data support a role for HCaRG in kidney repair after injury through its effect on renal cell migration and TGF-alpha secretion
      Title: HCaRG increases renal cell migration by a TGF-alpha autocrine loop mechanism.
    3. Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats.
      Title: Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.
    4. HCaRG regulates renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest
      Title: HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proximal tubule morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COMM domain-containing protein 5
    Names
    hypertension-related calcium-regulated gene protein
    hypertension-related, calcium regulated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433925.1 → NP_001420854.1  COMM domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9ERR2
      UniProtKB/TrEMBL
      A6HSE1, G3V6K0

    2. NM_001433926.1 → NP_001420855.1  COMM domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9ERR2
      UniProtKB/TrEMBL
      A6HSE1, G3V6K0

    3. NM_001433927.1 → NP_001420856.1  COMM domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9ERR2
      UniProtKB/TrEMBL
      A6HSE1, G3V6K0

    4. NM_139108.3 → NP_620808.2  COMM domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9ERR2
      UniProtKB/TrEMBL
      A6HSE1, G3V6K0
      Related
      ENSRNOP00000077291.2, ENSRNOT00000100252.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110502492..110503916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERR2.1 GenPept UniProtKB/Swiss-Prot:Q9ERR2

    Gene LinkOut

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