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    Kirrel3 kirre like nephrin family adhesion molecule 3 [ Mus musculus (house mouse) ]

    Gene ID: 67703, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kirrel3provided by MGI
    Official Full Name
    kirre like nephrin family adhesion molecule 3provided by MGI
    Primary source
    MGI:MGI:1914953
    See related
    Ensembl:ENSMUSG00000032036 AllianceGenome:MGI:1914953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SST4; NEPH2; mKIAA1867; 1500010O20Rik; 2900036G11Rik
    Summary
    Predicted to enable cell adhesion molecule binding activity. Involved in hemopoiesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Acts upstream of or within glomerulus morphogenesis; inter-male aggressive behavior; and nervous system development. Located in several cellular components, including axon; dendritic shaft; and extracellular region. Is expressed in several structures, including Rathke's pouch; branchial arch; central nervous system; limb bud; and sensory organ. Orthologous to human KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 9.9), frontal lobe adult (RPKM 5.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kirrel3 in Genome Data Viewer
    Location:
    9 A4; 9 18.97 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (34396850..34952103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (34485853..35040807)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 7630403G23 gene Neighboring gene predicted gene, 32359 Neighboring gene STARR-seq mESC enhancer starr_23752 Neighboring gene STARR-seq mESC enhancer starr_23754 Neighboring gene predicted gene, 33777 Neighboring gene predicted gene, 33561 Neighboring gene kirre like nephrin family adhesion molecule 3, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E3822 Neighboring gene STARR-seq mESC enhancer starr_23759 Neighboring gene RIKEN cDNA 4930581F22 gene Neighboring gene STARR-seq mESC enhancer starr_23763 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene predicted gene, 51705 Neighboring gene predicted gene, 57537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference. Choi SY, et al. Front Cell Neurosci, 2015. PMID 26283919, Free PMC Article
    2. Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain. Hisaoka T, et al. Biochem Biophys Res Commun, 2021 Jul 23. PMID 34062388
    3. Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants. Taylor MR, et al. J Neurosci, 2020 Jul 8. PMID 32503885, Free PMC Article
    4. Increased Excitatory Synaptic Transmission of Dentate Granule Neurons in Mice Lacking PSD-95-Interacting Adhesion Molecule Neph2/Kirrel3 during the Early Postnatal Period. Roh JD, et al. Front Mol Neurosci, 2017. PMID 28381988, Free PMC Article
    5. Adhesion molecule Kirrel3/Neph2 is required for the elongated shape of myocytes during skeletal muscle differentiation. Tamir-Livne Y, et al. Int J Dev Biol, 2017. PMID 28621431

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
      Title: Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors.
    2. Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain.
      Title: Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain.
    3. Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants.
      Title: Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants.
    4. Kirrel2 is required for axonal coalescence in subsets of Olfactory sensory neurons that project axons to the DII (dorsal) region; Kirrel2/3-independent mechanisms also control olfactory sensory neurons axonal coalescence in certain regions of the Olfactory bulb.
      Title: Kirrel2 is differentially required in populations of olfactory sensory neurons for the targeting of axons in the olfactory bulb.
    5. The results of this study demonstrate that Kirrel2 and Kirrel3 are essential for the formation of glomeruli and suggest they contribute to synaptogenesis in the accessory olfactory bulb.
      Title: Loss of Kirrel family members alters glomerular structure and synapse numbers in the accessory olfactory bulb.
    6. Findings provide evidence that Kirrel3(-/-) mice exhibit autistic-like behaviors, including social and communicative deficits, repetitive behaviors, and sensory abnormalities, as well as hyperactivity.
      Title: Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice.
    7. This study demonstrated that selective loss of mossy fiber filopodial synapses with GABA neurons likely underlies the hippocampal activity imbalance observed in Kirrel3 knockout mice and may impact neural function in patients with Kirrel3-dependent neurodevelopmental disorders.
      Title: Examining Hippocampal Mossy Fiber Synapses by 3D Electron Microscopy in Wildtype and Kirrel3 Knockout Mice.
    8. mouse Kirrel3 is a myobast adhesion molecule which promotes the morphological change of rounded MPC to a spindle shaped myocyte that migrates in a directed fashion and participates in the tight interactions between myocytes prior to their fusion
      Title: Adhesion molecule Kirrel3/Neph2 is required for the elongated shape of myocytes during skeletal muscle differentiation.
    9. Kirrel3 is required for formation of hippocampal mossy fiber filopodia; the structures that give rise to dentate granule-GABA synapses and that regulate feed-forward inhibition of CA3 neurons.
      Title: The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus.
    10. Kirrel3 has a role in coalescence of vomeronasal sensory neuron axons into glomeruli and in male-male aggression in a resident-intruder assay
      Title: Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glomerulus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within principal sensory nucleus of trigeminal nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kin of IRRE-like protein 3
    Names
    X kin of IRRE like 3
    kin of IRRE like 3
    kin of irregular chiasm-like protein 3
    membrane protein mKirre
    nephrin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190911.2 → NP_001177840.1  kin of IRRE-like protein 3 isoform A precursor

      See identical proteins and their annotated locations for NP_001177840.1

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639
      UniProtKB/Swiss-Prot
      Q6P555, Q810H3, Q8BGQ5, Q8BR86, Q8BRS8
      Conserved Domains (4) summary
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    2. NM_001190912.2 → NP_001177841.1  kin of IRRE-like protein 3 isoform C precursor

      See identical proteins and their annotated locations for NP_001177841.1

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639
      Consensus CDS
      CCDS80973.1
      UniProtKB/TrEMBL
      Q3TAG1
      Related
      ENSMUSP00000140219.2, ENSMUST00000187182.7
      Conserved Domains (4) summary
      cd05759
      Location:139 → 220
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:392 → 489
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00409
      Location:28 → 117
      IG; Immunoglobulin
      cl11960
      Location:309 → 390
      Ig; Immunoglobulin domain

    3. NM_001190913.2 → NP_001177842.1  kin of IRRE-like protein 3 isoform D precursor

      See identical proteins and their annotated locations for NP_001177842.1

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639
      UniProtKB/TrEMBL
      A0A087WPC0
      Related
      ENSMUSP00000139714.2, ENSMUST00000190549.7
      Conserved Domains (7) summary
      cd05759
      Location:165 → 246
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:418 → 515
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00408
      Location:349 → 400
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:426 → 515
      IG_like; Immunoglobulin like
      pfam07679
      Location:335 → 416
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:254 → 318
      Ig_3; Immunoglobulin domain
      cl11960
      Location:52 → 143
      Ig; Immunoglobulin domain

    4. NM_001190914.2 → NP_001177843.1  kin of IRRE-like protein 3 isoform E

      See identical proteins and their annotated locations for NP_001177843.1

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639
      Consensus CDS
      CCDS57667.1
      UniProtKB/TrEMBL
      G5E8B6, Q3TAG1
      Related
      ENSMUSP00000048863.7, ENSMUST00000045091.13
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    5. NM_001433785.1 → NP_001420714.1  kin of IRRE-like protein 3 isoform F precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    6. NM_001433786.1 → NP_001420715.1  kin of IRRE-like protein 3 isoform G precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    7. NM_001433787.1 → NP_001420716.1  kin of IRRE-like protein 3 isoform H precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    8. NM_001433788.1 → NP_001420717.1  kin of IRRE-like protein 3 isoform I

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639, AC156641

    9. NM_001433789.1 → NP_001420718.1  kin of IRRE-like protein 3 isoform J

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639, AC156641

    10. NM_001433790.1 → NP_001420719.1  kin of IRRE-like protein 3 isoform K precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    11. NM_001433791.1 → NP_001420720.1  kin of IRRE-like protein 3 isoform L precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    12. NM_001433792.1 → NP_001420721.1  kin of IRRE-like protein 3 isoform M precursor

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639

    13. NM_026324.4 → NP_080600.1  kin of IRRE-like protein 3 isoform B precursor

      See identical proteins and their annotated locations for NP_080600.1

      Status: VALIDATED

      Source sequence(s)
      AC155250, AC156639
      Consensus CDS
      CCDS40574.1
      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (4) summary
      cd05759
      Location:165 → 246
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:418 → 515
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00410
      Location:54 → 143
      IG_like; Immunoglobulin like
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      34396850..34952103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155204.1 → XP_036011097.1  kin of IRRE-like protein 3 isoform X1

      Conserved Domains (5) summary
      smart00410
      Location:54 → 143
      IG_like; Immunoglobulin like
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    2. XM_006510557.5 → XP_006510620.1  kin of IRRE-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006510620.1

      Conserved Domains (5) summary
      smart00410
      Location:54 → 143
      IG_like; Immunoglobulin like
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    3. XM_006510560.5 → XP_006510623.1  kin of IRRE-like protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006510623.1

      UniProtKB/Swiss-Prot
      Q6P555, Q810H3, Q8BGQ5, Q8BR86, Q8BRS8
      Conserved Domains (4) summary
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    4. XM_006510559.5 → XP_006510622.1  kin of IRRE-like protein 3 isoform X2

      Conserved Domains (4) summary
      cd05759
      Location:165 → 246
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:418 → 515
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00409
      Location:54 → 143
      IG; Immunoglobulin
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    5. XM_006510563.5 → XP_006510626.1  kin of IRRE-like protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006510626.1

      UniProtKB/TrEMBL
      Q3TAG1
      Related
      ENSMUSP00000110801.3, ENSMUST00000115148.9
      Conserved Domains (4) summary
      cd05759
      Location:165 → 246
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:418 → 515
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00410
      Location:54 → 143
      IG_like; Immunoglobulin like
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    6. XM_006510558.5 → XP_006510621.1  kin of IRRE-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006510621.1

      Conserved Domains (5) summary
      smart00410
      Location:54 → 143
      IG_like; Immunoglobulin like
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    7. XM_036155205.1 → XP_036011098.1  kin of IRRE-like protein 3 isoform X3

      UniProtKB/Swiss-Prot
      Q6P555, Q810H3, Q8BGQ5, Q8BR86, Q8BRS8
      Conserved Domains (4) summary
      cd00096
      Location:343 → 347
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:149 → 246
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:418 → 515
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:335 → 416
      Ig; Immunoglobulin domain

    8. XM_006510561.5 → XP_006510624.1  kin of IRRE-like protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006510624.1

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (4) summary
      cd05759
      Location:139 → 220
      Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
      cd05898
      Location:392 → 489
      Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
      smart00409
      Location:28 → 117
      IG; Immunoglobulin
      cl11960
      Location:309 → 390
      Ig; Immunoglobulin domain

    9. XM_036155207.1 → XP_036011100.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    10. XM_036155211.1 → XP_036011104.1  kin of IRRE-like protein 3 isoform X7

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:28 → 117
      IG_like; Immunoglobulin like
      cd00096
      Location:317 → 321
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:123 → 220
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:392 → 489
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:309 → 390
      Ig; Immunoglobulin domain

    11. XM_036155206.1 → XP_036011099.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    12. XM_036155208.1 → XP_036011101.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    13. XM_036155213.1 → XP_036011106.1  kin of IRRE-like protein 3 isoform X9

      UniProtKB/TrEMBL
      G5E8B6, Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    14. XM_036155210.1 → XP_036011103.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    15. XM_030244529.2 → XP_030100389.1  kin of IRRE-like protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A087WNM9, Q3TAG1
      Related
      ENSMUSP00000139418.2, ENSMUST00000188933.7
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    16. XM_036155214.1 → XP_036011107.1  kin of IRRE-like protein 3 isoform X9

      UniProtKB/TrEMBL
      G5E8B6, Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    17. XM_036155209.1 → XP_036011102.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    18. XM_017313538.3 → XP_017169027.1  kin of IRRE-like protein 3 isoform X5

      UniProtKB/TrEMBL
      Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    19. XM_017313539.3 → XP_017169028.1  kin of IRRE-like protein 3 isoform X9

      UniProtKB/TrEMBL
      G5E8B6, Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain

    20. XM_036155212.1 → XP_036011105.1  kin of IRRE-like protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A087WNM9, Q3TAG1
      Conserved Domains (5) summary
      smart00410
      Location:21 → 110
      IG_like; Immunoglobulin like
      cd00096
      Location:310 → 314
      Ig; Ig strand A' [structural motif]
      cd05759
      Location:116 → 213
      IgI_2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05898
      Location:385 → 482
      IgI_5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:302 → 383
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BR86.1 GenPept UniProtKB/Swiss-Prot:Q8BR86

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