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    Zasp66 Z band alternatively spliced PDZ-motif protein 66 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38988, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Zasp66provided by FlyBase
    Official Full Name
    Z band alternatively spliced PDZ-motif protein 66provided by FlyBase
    Primary source
    FLYBASE:FBgn0035917
    Locus tag
    Dmel_CG6416
    See related
    AllianceGenome:FB:FBgn0035917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.30; CG6416; Dmel\CG6416; Zaps66; ZASP66
    Summary
    Enables muscle alpha-actinin binding activity and protein phosphatase 1 binding activity. Involved in mesoderm development and myofibril assembly. Located in Z disc. Is expressed in adult head; adult heart; adult muscle cell; embryonic/larval midgut; and somatic muscle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including PDLIM1 (PDZ and LIM domain 1); PDLIM2 (PDZ and LIM domain 2); and PDLIM3 (PDZ and LIM domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zasp66 in Genome Data Viewer
    Location:
    66D9-66D9; 3-26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8624371..8638813)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8617471..8631913)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Cell division cycle 6 Neighboring gene Cuticular protein 66D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The unexpected versatility of ALP/Enigma family proteins. Fisher LAB, et al. Front Cell Dev Biol, 2022. PMID 36531944, Free PMC Article
    2. Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Clark KA, et al. Cytoskeleton (Hoboken), 2013 Jun. PMID 23606669, Free PMC Article
    3. Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils. González-Morales N, et al. Genetics, 2019 Jul. PMID 31123042, Free PMC Article
    4. Nucleus-dependent sarcomere assembly is mediated by the LINC complex. Auld AL, et al. Mol Biol Cell, 2016 Aug 1. PMID 27307582, Free PMC Article
    5. Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila. González-Morales N, et al. Elife, 2019 Nov 20. PMID 31746737, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zasp66 null mutant has limited viability, but only mild indirect flight muscle defects.
      Title: Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils.
    2. Zasp52 and Zasp66 directly bind to alpha-actinin, and they can also form a ternary complex.
      Title: Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables muscle alpha-actinin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in muscle structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Z band alternatively spliced PDZ-motif protein 66
    Names
    CG6416-PA
    CG6416-PB
    CG6416-PE
    CG6416-PF
    CG6416-PG
    CG6416-PH
    CG6416-PI
    CG6416-PJ
    CG6416-PK
    CG6416-PM
    CG6416-PN
    CG6416-PO
    Zasp66-PA
    Zasp66-PB
    Zasp66-PE
    Zasp66-PF
    Zasp66-PG
    Zasp66-PH
    Zasp66-PI
    Zasp66-PJ
    Zasp66-PK
    Zasp66-PM
    Zasp66-PN
    Zasp66-PO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8624371..8638813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169914.3 → NP_001163385.1  Z band alternatively spliced PDZ-motif protein 66, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI73
      Conserved Domains (2) summary
      cd00992
      Location:68 → 115
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:285 → 393
      DUF4749; Domain of unknown function (DUF4749)

    2. NM_168283.4 → NP_729395.2  Z band alternatively spliced PDZ-motif protein 66, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729395.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQB4
      Related
      FBpp0088529
      Conserved Domains (2) summary
      cd00992
      Location:68 → 115
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:285 → 359
      DUF4749; Domain of unknown function (DUF4749)

    3. NM_001169915.2 → NP_001163386.1  Z band alternatively spliced PDZ-motif protein 66, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI74
      Conserved Domains (2) summary
      cd00992
      Location:68 → 115
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:285 → 314
      DUF4749; Domain of unknown function (DUF4749)

    4. NM_168284.3 → NP_729396.2  Z band alternatively spliced PDZ-motif protein 66, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729396.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQB3, Q95TZ7
      Related
      FBpp0088531
      Conserved Domains (2) summary
      cd00992
      Location:10 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:257 → 331
      DUF4749; Domain of unknown function (DUF4749)

    5. NM_001169913.1 → NP_001163384.1  Z band alternatively spliced PDZ-motif protein 66, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4L4, E1JI76
      Conserved Domains (2) summary
      cd00992
      Location:10 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:257 → 314
      DUF4749; Domain of unknown function (DUF4749)

    6. NM_001169911.1 → NP_001163382.1  Z band alternatively spliced PDZ-motif protein 66, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058U1
      Conserved Domains (2) summary
      cd00992
      Location:10 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:257 → 365
      DUF4749; Domain of unknown function (DUF4749)

    7. NM_139989.4 → NP_648246.3  Z band alternatively spliced PDZ-motif protein 66, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648246.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4L4, Q7KUB5
      Conserved Domains (2) summary
      cd00992
      Location:10 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:257 → 286
      DUF4749; Domain of unknown function (DUF4749)

    8. NM_176303.5 → NP_788481.1  Z band alternatively spliced PDZ-motif protein 66, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BH6
      Related
      FBpp0088534
      Conserved Domains (1) summary
      pfam15936
      Location:94 → 158
      DUF4749; Domain of unknown function (DUF4749)

    9. NM_176304.5 → NP_788482.1  Z band alternatively spliced PDZ-motif protein 66, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BH5
      Related
      FBpp0088533
      Conserved Domains (1) summary
      pfam15936
      Location:94 → 123
      DUF4749; Domain of unknown function (DUF4749)

    10. NM_176306.3 → NP_788484.2  Z band alternatively spliced PDZ-motif protein 66, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788484.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSN2
      Related
      FBpp0088535
      Conserved Domains (1) summary
      pfam15936
      Location:94 → 182
      DUF4749; Domain of unknown function (DUF4749)

    11. NM_168286.4 → NP_729398.1  Z band alternatively spliced PDZ-motif protein 66, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSN2
      Related
      FBpp0088530
      Conserved Domains (1) summary
      pfam15936
      Location:94 → 182
      DUF4749; Domain of unknown function (DUF4749)

    12. NM_176305.4 → NP_788483.1  Z band alternatively spliced PDZ-motif protein 66, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSN0
      Related
      FBpp0088532
      Conserved Domains (1) summary
      pfam15936
      Location:94 → 121
      DUF4749; Domain of unknown function (DUF4749)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI73 E1JI73
    E1JI74 E1JI74
    E1JI76 E1JI76
    Q058U1 Q058U1
    Q7KUB5 Q7KUB5
    Q86BH5 Q86BH5
    Q86BH6 Q86BH6
    Q8IQB4 Q8IQB4
    Q95S47 Q95S47
    Q95TZ7 Q95TZ7
    Q9VSN0 Q9VSN0
    Q9VSN2 Q9VSN2

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