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    Vha55 Vacuolar H[+]-ATPase 55kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41550, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Vha55provided by FlyBase
    Official Full Name
    Vacuolar H[+]-ATPase 55kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005671
    Locus tag
    Dmel_CG17369
    See related
    AllianceGenome:FB:FBgn0005671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1208/13; ATP6V1B1; CG17369; Dmel\CG17369; l(3)87Ca; l(3)j2E9; l(3)SzA; SzA; v-ATPase; V-ATPase; V-type H+-ATPase; VA; VAT-2; vha55
    Summary
    Contributes to proton-transporting ATPase activity, rotational mechanism. Involved in proton transmembrane transport and vacuolar acidification. Located in brush border; early endosome; and perinuclear region of cytoplasm. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including Malpighian tubule; adult CNS glial cell; anterior-posterior subdivision of organism; gland; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to several human genes including ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha55 in Genome Data Viewer
    Location:
    87C2-87C3; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12623762..12627829, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8449484..8453551, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46017 Neighboring gene long non-coding RNA:CR44942 Neighboring gene Sorting nexin 3 Neighboring gene CCR4-NOT transcription complex subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletions of two heat-activated loci in Drosophila melanogaster and their effects on heat-induced protein synthesis. Ish-Horowicz D, et al. Cell, 1977 Nov. PMID 411575
    2. The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Du J, et al. J Cell Sci, 2006 Jun 15. PMID 16735441
    3. Involvement of V-ATPase in the regulation of cell size in the fly's visual system. Pyza E, et al. J Insect Physiol, 2004 Nov. PMID 15607501
    4. Vacuolar ATPase is required for ERK-dependent wound healing in the Drosophila embryo. Fraire-Zamora JJ, et al. Wound Repair Regen, 2018 Jan. PMID 29418044
    5. The roles of V-type H(+)-ATPase and Na(+)/K(+)-ATPase in energizing K(+) and H(+) transport in larval Drosophila gut epithelia. D'Silva NM, et al. J Insect Physiol, 2017 Apr. PMID 28188726

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar acidification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+]-ATPase 55kD subunit
    Names
    B subunit
    B subunit of V-ATPase
    CG17369-PA
    CG17369-PB
    CG17369-PC
    V-ATPase B-subunit
    V-ATPase subunit B
    V1 B subunit
    Vha55-PA
    Vha55-PB
    Vha55-PC
    vacuolar ATP synthase subunit B
    vacuolar ATPase B subunit
    vacuolar H+-ATPase 55kD B subunit
    vacuolar H+ATPase subunit B
    vacuolar H[+]-ATPase
    vacuolar H[+]-ATPase 55-kDa B subunit
    vacuolar H[+]-ATPase 55kD B subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12623762..12627829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057560.4 → NP_476908.1  vacuolar H[+]-ATPase 55kD subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31409, Q53YH8, Q9VG52
      UniProtKB/TrEMBL
      E1JIJ5
      Related
      FBpp0082139
      Conserved Domains (1) summary
      TIGR01040
      Location:25 → 488
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    2. NM_169475.2 → NP_731726.1  vacuolar H[+]-ATPase 55kD subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731726.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31409, Q53YH8, Q9VG52
      UniProtKB/TrEMBL
      E1JIJ5
      Related
      FBpp0082140
      Conserved Domains (1) summary
      TIGR01040
      Location:25 → 488
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

    3. NM_001170126.1 → NP_001163597.1  vacuolar H[+]-ATPase 55kD subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31409, Q53YH8, Q9VG52
      UniProtKB/TrEMBL
      E1JIJ5
      Conserved Domains (1) summary
      TIGR01040
      Location:25 → 488
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIJ5 E1JIJ5
    P31409.1 P31409

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