U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    C3G C3G guanyl-nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31618, updated on 9-Dec-2024

    Summary

    Official Symbol
    C3Gprovided by FlyBase
    Official Full Name
    C3G guanyl-nucleotide exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259228
    Locus tag
    Dmel_CG42328
    See related
    AllianceGenome:FB:FBgn0259228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c(3)G; C(3)G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\CG42328
    Old locus tag
    Dmel_CG14436; Dmel_CG3126
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including Ras protein signal transduction; positive regulation of smoothened signaling pathway; and sarcomere organization. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; gut section; larval central nervous system; somatic mesoderm; and visceral mesoderm. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See C3G in Genome Data Viewer
    Location:
    6D1-6D2; 1-18 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6780790..6803593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6674823..6697626, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43496 Neighboring gene small ovary Neighboring gene Coenzyme Q7 Neighboring gene shifted Neighboring gene pod1 coronin Neighboring gene inactive

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    C3G guanyl-nucleotide exchange factor
    Names
    C3G ortholog
    C3G-PC
    C3G-PD
    C3G-PE
    C3G-PF
    C3G-PG
    C3G-PH
    C3G-PI
    C3G-PJ
    C3G-PK
    C3G-PL
    CG42328-PC
    CG42328-PD
    CG42328-PE
    CG42328-PF
    CG42328-PG
    CG42328-PH
    CG42328-PI
    CG42328-PJ
    CG42328-PK
    CG42328-PL

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6780790..6803593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298037.1NP_001284966.1  C3G guanyl-nucleotide exchange factor, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JIR4
      Conserved Domains (2) summary
      smart00229
      Location:9561092
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:11211344
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. NM_176694.3NP_788867.1  C3G guanyl-nucleotide exchange factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788867.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77086
      Related
      FBpp0289069
      Conserved Domains (2) summary
      smart00229
      Location:11191255
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:12841507
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    3. NM_001272362.1NP_001259291.1  C3G guanyl-nucleotide exchange factor, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJ95
      Conserved Domains (2) summary
      smart00229
      Location:10131149
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:11781401
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    4. NM_001144695.3NP_001138167.1  C3G guanyl-nucleotide exchange factor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z129
      Conserved Domains (2) summary
      smart00229
      Location:10161152
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:11811404
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    5. NM_001272364.1NP_001259293.1  C3G guanyl-nucleotide exchange factor, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGJ9
      Conserved Domains (2) summary
      smart00229
      Location:10671203
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:12321455
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    6. NM_001144696.3NP_001138168.1  C3G guanyl-nucleotide exchange factor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z130
      Conserved Domains (2) summary
      smart00229
      Location:10671203
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:12321455
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    7. NM_001144697.2NP_001138169.1  C3G guanyl-nucleotide exchange factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z131
      Conserved Domains (2) summary
      smart00229
      Location:833969
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:9981221
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    8. NM_001144694.2NP_001138166.1  C3G guanyl-nucleotide exchange factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z132
      Conserved Domains (2) summary
      smart00229
      Location:8841020
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:10491272
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    9. NM_001272363.1NP_001259292.1  C3G guanyl-nucleotide exchange factor, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z131
      Conserved Domains (2) summary
      smart00229
      Location:833969
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:9981221
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    10. NM_132122.5NP_572350.2  C3G guanyl-nucleotide exchange factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572350.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77086, Q1ECB6, Q7YU30, Q86B63, Q9W3W3
      Related
      FBpp0289753
      Conserved Domains (2) summary
      smart00229
      Location:11701306
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:13351558
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...