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    g6pd glucose-6-phosphate dehydrogenase [ Danio rerio (zebrafish) ]

    Gene ID: 570579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    g6pdprovided by ZNC
    Official Full Name
    glucose-6-phosphate dehydrogenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070508-4
    See related
    Ensembl:ENSDARG00000071065 AllianceGenome:ZFIN:ZDB-GENE-070508-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj78b06; wu:fj78b06; si:dkey-90a13.8
    Summary
    Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Predicted to be active in cytosol. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See g6pd in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (13844920..13874758, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (14088843..14118717, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene leiomodin 3 (fetal) Neighboring gene N-alpha-acetyltransferase 10, NatA catalytic subuni Neighboring gene uncharacterized LOC108181454 Neighboring gene sperm microtubule inner protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish. Patrinostro X, et al. Exp Hematol, 2013 Aug. PMID 23603363, Free PMC Article
    2. Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Wang X, et al. Phytomedicine, 2022 Jul 20. PMID 35576740, Free PMC Article
    3. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Hwang S, et al. Nat Commun, 2018 Oct 2. PMID 30279493, Free PMC Article
    4. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Arogbokun O, et al. Sci Rep, 2020 Nov 5. PMID 33154437, Free PMC Article
    5. SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Tan VWT, et al. Dev Cell, 2024 Apr 8. PMID 38366599

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
      Title: The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epiboly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate 1-dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      13844920..13874758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694076.9 → XP_699168.3  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PT34, F6NHI0
      Related
      ENSDARP00000115363.1, ENSDART00000138696.2
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_005162010.5 → XP_005162067.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B959
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_009296703.4 → XP_009294978.2  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY75
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068216878.1 → XP_068072979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    5. XM_068216877.1 → XP_068072978.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Related
      ENSDARP00000151797.1, ENSDART00000193807.1

    6. XM_009296704.4 → XP_009294979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      See identical proteins and their annotated locations for XP_009294979.1

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    7. XM_009296706.4 → XP_009294981.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      See identical proteins and their annotated locations for XP_009294981.1

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Related
      ENSDARP00000095604.4, ENSDART00000104834.6
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    8. XM_021469916.2 → XP_021325591.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    9. XM_017353737.3 → XP_017209226.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395134.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      153055..182734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473587.2 → XP_021329262.1  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PDT5
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_021473585.2 → XP_021329260.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7P5
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_021473586.2 → XP_021329261.1  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q3J7
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068219028.1 → XP_068075129.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3

    5. XM_021473588.2 → XP_021329263.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    6. XM_021473590.2 → XP_021329265.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395358.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      61063..90901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474503.2 → XP_021330178.1  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PT34, F6NHI0
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_021474501.2 → XP_021330176.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B959
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_021474502.2 → XP_021330177.1  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY75
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068219381.1 → XP_068075482.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    5. XM_068219380.1 → XP_068075481.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    6. XM_021474504.2 → XP_021330179.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    7. XM_021474506.2 → XP_021330181.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    8. XM_021474505.2 → XP_021330180.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    9. XM_021474507.2 → XP_021330182.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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