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    gramd1c GRAM domain containing 1c [ Danio rerio (zebrafish) ]

    Gene ID: 563054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gramd1cprovided by ZNC
    Official Full Name
    GRAM domain containing 1cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050506-88
    See related
    Ensembl:ENSDARG00000076238 AllianceGenome:ZFIN:ZDB-GENE-050506-88
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe11c03; im:6904950; wu:fe11c03; si:ch73-93k15.2
    Summary
    Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gramd1c in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21132978..21150040, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20988662..21005604, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 191 Neighboring gene zinc finger DHHC-type palmitoyltransferase 23b Neighboring gene uncharacterized LOC137489236 Neighboring gene ATPase H+ transporting V1 subunit Ab Neighboring gene N-alpha-acetyltransferase 50, NatE catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain-containing protein 1C; protein Aster-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      21132978..21150040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162729.5 → XP_005162786.1  protein Aster-C

      See identical proteins and their annotated locations for XP_005162786.1

      UniProtKB/TrEMBL
      A0A8M2B9S9, E7F236
      Related
      ENSDARP00000129043.1, ENSDART00000154249.2
      Conserved Domains (2) summary
      cd13220
      Location:97 → 187
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:357 → 503
      DUF4782; Domain of unknown function (DUF4782)

    2. XM_683292.10 → XP_688384.5  protein Aster-C

      See identical proteins and their annotated locations for XP_688384.5

      UniProtKB/TrEMBL
      A0A8M2B9S9, E7F236
      Related
      ENSDARP00000146528.1, ENSDART00000193256.1
      Conserved Domains (2) summary
      cd13220
      Location:97 → 187
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:357 → 503
      DUF4782; Domain of unknown function (DUF4782)

    RNA

    1. XR_002456628.2 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395170.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      149089..166572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473760.2 → XP_021329435.1  protein Aster-C

      UniProtKB/TrEMBL
      A0A8M9Q853
      Conserved Domains (2) summary
      cd13220
      Location:95 → 187
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:357 → 505
      DUF4782; Domain of unknown function (DUF4782)

    2. XM_021473759.2 → XP_021329434.1  protein Aster-C

      UniProtKB/TrEMBL
      A0A8M9Q853
      Conserved Domains (2) summary
      cd13220
      Location:95 → 187
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:357 → 505
      DUF4782; Domain of unknown function (DUF4782)
    Nucleotide Protein
    Heading Accession and Version

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