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    gulp1a GULP PTB domain containing engulfment adaptor 1a [ Danio rerio (zebrafish) ]

    Gene ID: 368404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gulp1aprovided by ZNC
    Official Full Name
    GULP PTB domain containing engulfment adaptor 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-21
    See related
    Ensembl:ENSDARG00000001733 AllianceGenome:ZFIN:ZDB-GENE-030616-21
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CED-6; gulp1; wu:fj61e02; si:by35d8.1; si:xx-35d8.1; si:ch211-198b21.4
    Summary
    Predicted to act upstream of or within apoptotic process and phagocytosis. Predicted to be located in cytoplasm. Is expressed in immature eye; midbrain; notochord; and pharyngeal arch. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gulp1a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (42546716..42650187)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (42805369..42848392)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911686 Neighboring gene uncharacterized LOC137496413 Neighboring gene tissue factor pathway inhibitor a Neighboring gene uncharacterized LOC137496417 Neighboring gene collagen, type V, alpha 2a Neighboring gene FKBP prolyl isomerase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. Martins R, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 24815885
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123057

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PTB domain-containing engulfment adapter protein 1
    Names
    GULP, engulfment adaptor PTB domain containing 1
    GULP, engulfment adaptor PTB domain containing 1a
    PTB domain adapter protein CED-6
    cell death protein 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007182.4 → NP_001007183.1  PTB domain-containing engulfment adapter protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001007183.1

      Status: VALIDATED

      Source sequence(s)
      AW282049, BX640465, CT643886, EB836043, EB928166, EH555841, EH576944
      UniProtKB/Swiss-Prot
      A2AI65, B0S741, B0S742, Q32PV0
      Related
      ENSDARP00000000920.10, ENSDART00000002027.11
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam04880
      Location:152 → 243
      NUDE_C; NUDE protein, C-terminal conserved region

    2. NM_001423684.1 → NP_001410613.1  PTB domain-containing engulfment adapter protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW282049, BX640465, CT643886, EB836043, EH576944, GFIL01012210
      Related
      ENSDARP00000114797.1, ENSDART00000138133.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      42546716..42650187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223306.1 → XP_068079407.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    2. XM_068223305.1 → XP_068079406.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    3. XM_068223304.1 → XP_068079405.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    4. XM_068223314.1 → XP_068079415.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    5. XM_068223313.1 → XP_068079414.1  PTB domain-containing engulfment adapter protein 1 isoform X6

    6. XM_068223308.1 → XP_068079409.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    7. XM_068223316.1 → XP_068079417.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      A2AI65, B0S741, B0S742, Q32PV0

    8. XM_068223311.1 → XP_068079412.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    9. XM_068223307.1 → XP_068079408.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    10. XM_068223315.1 → XP_068079416.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      A2AI65, B0S741, B0S742, Q32PV0
      Related
      ENSDARP00000150288.1, ENSDART00000192224.1

    11. XM_068223312.1 → XP_068079413.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    12. XM_068223309.1 → XP_068079410.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    13. XM_068223317.1 → XP_068079418.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      A2AI65, B0S741, B0S742, Q32PV0

    14. XM_068223310.1 → XP_068079411.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PV0.1 GenPept UniProtKB/Swiss-Prot:Q32PV0

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