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    magi1a membrane associated guanylate kinase, WW and PDZ domain containing 1a [ Danio rerio (zebrafish) ]

    Gene ID: 100319849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    magi1aprovided by ZNC
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081105-13
    See related
    Ensembl:ENSDARG00000070145 AllianceGenome:ZFIN:ZDB-GENE-081105-13
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch1073-268b21.1
    Summary
    Predicted to enable kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See magi1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (54054702..54075090)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53645587..53667665)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene sushi domain-containing protein 3 Neighboring gene serine/threonine-protein kinase WNK2 Neighboring gene prickle homolog 2a Neighboring gene rhodopsin Neighboring gene uncharacterized LOC100332221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. Groh KJ, et al. Gen Comp Endocrinol, 2013 Nov 1. PMID 23968773
    2. A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement. Kim OTP, et al. BMC Genomics, 2018 Oct 5. PMID 30290758, Free PMC Article
    3. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      54054702..54075090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478525.1 → XP_021334200.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QAB3, A0A8M9QJB9
      Conserved Domains (8) summary
      smart00228
      Location:434 → 515
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:264 → 293
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:956 → 1051
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:322 → 351
      WW; WW domain
      pfam04484
      Location:1303 → 1483
      DUF566; Family of unknown function (DUF566)
      pfam16663
      Location:175 → 219
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:692 → 787
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:95 → 166
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_068223244.1 → XP_068079345.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QAB3

    3. XM_068223245.1 → XP_068079346.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q456
      Related
      ENSDARP00000093471.4, ENSDART00000102696.5

    4. XM_068223246.1 → XP_068079347.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q456, A0A8M9QAC5
    Nucleotide Protein
    Heading Accession and Version

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