ncor2 nuclear receptor corepressor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncor2provided by ZNC
Official Full Name: nuclear receptor corepressor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-81
See related: Ensembl:ENSDARG00000000966 AllianceGenome:ZFIN:ZDB-GENE-030616-81
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SMRT; gb:be017685; si:bz71m17.2
Summary: Predicted to enable transcription corepressor activity. Acts upstream of or within hematopoietic stem cell differentiation; macrophage differentiation; and neutrophil differentiation. Predicted to be located in chromatin. Is expressed in several structures, including anterior axial hypoblast; cardiovascular system; central nervous system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (43379436..43574935, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (43372649..43568148, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
Title: Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis.
A novel regulatory mechanism for Ncor2 through Fos-Vegfd-Notch signaling cascade during hematopoietic stem cell development in zebrafish embryos.
Title: Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish.
rar-ncor2 corepressor complex may be part of an embryonic, epigenetic switch that keeps retinoic acid responsive genes off before retinoic becomes available to the embryo
Title: Identification and characterization of a functional zebrafish smrt corepressor (ncor2).

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General gene information

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Markers

Z789 (e-PCR)
- UniSTS:37183

fk82g02.x1 (e-PCR)
- UniSTS:201584

Z7130 (e-PCR)
- UniSTS:52148

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor corepressor 2

Names: nuclear receptor co-repressor 2; silencing mediator; thyroid hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007032.1 → NP_001007033.1 nuclear receptor corepressor 2

Status: VALIDATED

Source sequence(s)

AL590153, CABZ01054153, CABZ01054154, FO704626

UniProtKB/TrEMBL

A0A8M1N2Z2, E7FF48

Related

ENSDARP00000051138.6, ENSDART00000051139.7

Conserved Domains (5) summary

smart00717
Location:597 → 642

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:430 → 473

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

43379436..43574935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017357345.3 → XP_017212834.1 nuclear receptor corepressor 2 isoform X4

UniProtKB/TrEMBL

A0A8M6YZT2

Conserved Domains (5) summary

smart00717
Location:597 → 642

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:430 → 473

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_021478272.2 → XP_021333947.1 nuclear receptor corepressor 2 isoform X3

UniProtKB/TrEMBL

A0A8M9PQX3

Conserved Domains (7) summary

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl25496
Location:1998 → 2342

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:167 → 456

SMC_N; RecF/RecN/SMC N terminal domain

cl25751
Location:1288 → 1469

DUF4045; Domain of unknown function (DUF4045)

cl27154
Location:531 → 632

SWIRM; SWIRM domain
XM_017357343.3 → XP_017212832.1 nuclear receptor corepressor 2 isoform X2

UniProtKB/TrEMBL

A0A8M6Z833

Related

ENSDARP00000121486.1, ENSDART00000140618.3

Conserved Domains (5) summary

smart00717
Location:597 → 642

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:430 → 473

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_017357346.3 → XP_017212835.1 nuclear receptor corepressor 2 isoform X5

UniProtKB/TrEMBL

A0A8M6Z7M5

Conserved Domains (5) summary

smart00717
Location:597 → 642

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:430 → 473

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_009304185.4 → XP_009302460.1 nuclear receptor corepressor 2 isoform X1

See identical proteins and their annotated locations for XP_009302460.1

UniProtKB/TrEMBL

A0A8M3AVG1

Related

ENSDARP00000001475.8, ENSDART00000001092.10

Conserved Domains (7) summary

pfam00249
Location:597 → 640

Myb_DNA-binding; Myb-like DNA-binding domain

pfam03985
Location:640 → 728

Paf1; Paf1

pfam15784
Location:142 → 227

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl25496
Location:2014 → 2358

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl25732
Location:167 → 456

SMC_N; RecF/RecN/SMC N terminal domain

cl25751
Location:1304 → 1485

DUF4045; Domain of unknown function (DUF4045)

cl27154
Location:531 → 632

SWIRM; SWIRM domain