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    ctu1 cytosolic thiouridylase subunit 1 homolog (S. pombe) [ Danio rerio (zebrafish) ]

    Gene ID: 393098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctu1provided by ZNC
    Official Full Name
    cytosolic thiouridylase subunit 1 homolog (S. pombe)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-704
    See related
    Ensembl:ENSDARG00000020986 Ensembl:ENSDARG00000100247 AllianceGenome:ZFIN:ZDB-GENE-040426-704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55395
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to act upstream of or within lipid metabolic process and tRNA processing. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ctu1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (3423203..3439484)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (3364373..3380735)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 9b, tandem duplicate 1 Neighboring gene fucosyltransferase 9b, tandem duplicate 3 Neighboring gene fucosyltransferase 9b, tandem duplicate 6 Neighboring gene fucosyltransferase 9b, tandem duplicate 4 Neighboring gene fucosyltransferase 9b, tandem duplicate 5 Neighboring gene paxillin b Neighboring gene GCN1 activator of EIF2AK4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Jiang L, et al. Cell, 2013 May 9. PMID 23663777, Free PMC Article
    2. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55395

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein urmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic tRNA wobble base thiouridylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic tRNA 2-thiolation protein 1
    NP_956424.1
    XP_005172497.3
    XP_017212780.1
    XP_068078993.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200130.1 → NP_956424.1  cytoplasmic tRNA 2-thiolation protein 1

      See identical proteins and their annotated locations for NP_956424.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044158
      UniProtKB/Swiss-Prot
      A8WGP6, A9JRT6, Q803X1
      UniProtKB/TrEMBL
      B2GNZ1
      Related
      ENSDARP00000009303.7, ENSDART00000017850.9
      Conserved Domains (3) summary
      TIGR00269
      Location:204 → 305
      TIGR00269; TIGR00269 family protein
      COG0037
      Location:28 → 312
      TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
      cd01993
      Location:53 → 240
      Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      3423203..3439484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172440.5 → XP_005172497.3  cytoplasmic tRNA 2-thiolation protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BJT0

    2. XM_068222892.1 → XP_068078993.1  cytoplasmic tRNA 2-thiolation protein 1 isoform X2

      Related
      ENSDARP00000139431.1, ENSDART00000159466.2

    3. XM_017357291.3 → XP_017212780.1  cytoplasmic tRNA 2-thiolation protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z811
      Conserved Domains (2) summary
      pfam00852
      Location:190 → 367
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:66 → 172
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q803X1.1 GenPept UniProtKB/Swiss-Prot:Q803X1

    Gene LinkOut

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