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    cgnl1 cingulin-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553350, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cgnl1provided by ZNC
    Official Full Name
    cingulin-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071009-2
    See related
    Ensembl:ENSDARG00000015805 AllianceGenome:ZFIN:ZDB-GENE-071009-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in protein localization to cell-cell junction. Predicted to be part of myosin complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cgnl1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52431749..52498228, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52156732..52223169, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 93 Neighboring gene myocardial zonula adherens protein Neighboring gene transcription factor 12 Neighboring gene zinc finger protein 280D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Schwayer C, et al. Cell, 2019 Oct 31. PMID 31675500
    2. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in protein localization to cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cingulin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      52431749..52498228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003198999.6 → XP_003199047.1  cingulin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RNI0, F1R1I5
      Related
      ENSDARP00000104580.2, ENSDART00000129769.4
      Conserved Domains (9) summary
      COG1340
      Location:617 → 949
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam01496
      Location:1177 → 1258
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam03148
      Location:865 → 1237
      Tektin; Tektin family
      pfam05816
      Location:886 → 1093
      TelA; Toxic anion resistance protein (TelA)
      pfam11235
      Location:102 → 253
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam15035
      Location:826 → 948
      Rootletin; Ciliary rootlet component, centrosome cohesion
      pfam16043
      Location:604 → 729
      DUF4795; Domain of unknown function (DUF4795)
      cl02219
      Location:574 → 656
      Bap31; B-cell receptor-associated protein 31-like
      cl19219
      Location:767 → 849
      DUF342; Protein of unknown function (DUF342)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395268.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      259195..268485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474140.2 → XP_021329815.1  cingulin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q944
      Conserved Domains (1) summary
      cl25732
      Location:1 → 157
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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