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    myh10 myosin, heavy chain 10, non-muscle [ Danio rerio (zebrafish) ]

    Gene ID: 555454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myh10provided by ZNC
    Official Full Name
    myosin, heavy chain 10, non-muscleprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-162
    See related
    Ensembl:ENSDARG00000000103 AllianceGenome:ZFIN:ZDB-GENE-030616-162
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dZ204D19.2; wu:fc46h07; wu:fy19d11; si:dz150i12.3
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brain; eye; paraxial mesoderm; swim bladder bud; and tail bud. Orthologous to human MYH10 (myosin heavy chain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See myh10 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7553104..7658287)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7395905..7501116)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 3a Neighboring gene proliferation-associated 2G4, a Neighboring gene ubinuclein 2a Neighboring gene intraflagellar transport 56

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Huang Y, et al. Gene Expr Patterns, 2013 Oct. PMID 23665442
    2. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029
    3. Identification and localization of myosin superfamily members in fish retina and retinal pigmented epithelium. Lin-Jones J, et al. J Comp Neurol, 2009 Mar 10. PMID 19137585, Free PMC Article
    4. Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Georgijevic S, et al. Dev Dyn, 2007 Jun. PMID 17474123
    5. Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish. Myhre JL, et al. Dev Biol, 2014 Jun 1. PMID 24613615

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle distribution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-10
    Names
    myosin, heavy polypeptide 10, non-muscle
    nm-mhc-b
    nonmuscle myosin heavy chain B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      7553104..7658287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302145.4 → XP_009300420.1  myosin-10 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AT40, A0A8M3BA62
      Conserved Domains (8) summary
      cd14920
      Location:102 → 812
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:90 → 812
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:889 → 1969
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:37 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1705 → 1714
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:1085 → 1170
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:1641 → 1734
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1528 → 1637
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_009302149.4 → XP_009300424.1  myosin-10 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BD01, A0A8M3B073, F1R3G4, I3ISA3
      Related
      ENSDARP00000125918.1, ENSDART00000151114.2
      Conserved Domains (8) summary
      cd14920
      Location:102 → 790
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:90 → 790
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:867 → 1947
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:37 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1683 → 1692
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:1063 → 1148
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:1619 → 1712
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1506 → 1615
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_009302147.4 → XP_009300422.1  myosin-10 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AT40, A0A8M3B359
      Conserved Domains (8) summary
      cd14920
      Location:102 → 796
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:90 → 796
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:873 → 1953
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:37 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1689 → 1698
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:1069 → 1154
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:1625 → 1718
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1512 → 1621
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. XM_677954.10 → XP_683046.6  myosin-10 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BD01, A0A8N7USR7, I3ISA3
      Conserved Domains (8) summary
      cd14920
      Location:102 → 774
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:90 → 774
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:851 → 1931
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:37 → 75
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:1667 → 1676
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:1047 → 1132
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:1603 → 1696
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23720
      Location:1490 → 1597
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein Strain
    Heading Accession and Version

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