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    lztfl1 leucine zipper transcription factor-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 322226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lztfl1provided by ZNC
    Official Full Name
    leucine zipper transcription factor-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-945
    See related
    Ensembl:ENSDARG00000105010 AllianceGenome:ZFIN:ZDB-GENE-030131-945
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb53f12; zgc:56268; wu:fb53f12
    Summary
    Acts upstream of or within negative regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including gill; integument; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lztfl1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (12133889..12253332)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (11993716..12113191)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909743 Neighboring gene chemokine (C-C motif) receptor 9b Neighboring gene G2/M phase-specific E3 ubiquitin-protein ligase Neighboring gene uncharacterized LOC137489220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular Characterization and Functional Analysis of Leucine Zipper Transcription Factor Like 1 in Zebrafish (Danio rerio). Wei Q, et al. Front Physiol, 2019. PMID 31293455, Free PMC Article
    2. Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish. Grajevskaja V, et al. PLoS One, 2018. PMID 29933372, Free PMC Article
    3. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper transcription factor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199587.1 → NP_955881.1  leucine zipper transcription factor-like protein 1

      See identical proteins and their annotated locations for NP_955881.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046036
      UniProtKB/TrEMBL
      Q7ZV21
      Related
      ENSDARP00000139253.1, ENSDART00000168248.2
      Conserved Domains (1) summary
      pfam15294
      Location:20 → 291
      Leu_zip; Leucine zipper

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      12133889..12253332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217030.1 → XP_068073131.1  leucine zipper transcription factor-like protein 1 isoform X2

    2. XM_068217029.1 → XP_068073130.1  leucine zipper transcription factor-like protein 1 isoform X1

      Related
      ENSDARP00000140403.1, ENSDART00000159029.2
    Nucleotide Protein
    Heading Accession and Version

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