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    shdb Src homology 2 domain containing transforming protein D, b [ Danio rerio (zebrafish) ]

    Gene ID: 564537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shdbprovided by ZNC
    Official Full Name
    Src homology 2 domain containing transforming protein D, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6059
    See related
    Ensembl:ENSDARG00000062109 AllianceGenome:ZFIN:ZDB-GENE-030131-6059
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    shd; wu:fb38a12; wu:fi32h10; zgc:153246; zgc:153975; zgc:158798; si:dkeyp-31e2.2
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Is expressed in several structures, including nervous system; pectoral fin musculature; segmental plate; solid lens vesicle; and tail bud. Orthologous to human SHD (Src homology 2 domain containing transforming protein D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shdb in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (21398507..21471107)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (21373529..21440827)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene SHC (Src homology 2 domain containing) transforming protein 2 Neighboring gene ankyrin repeat domain 24 Neighboring gene sphingosine-1-phosphate receptor 3a Neighboring gene mesoderm induction early response 1, family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos. Wong KS, et al. Dev Dyn, 2009 Jul. PMID 19504456
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153246, MGC158798

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Src homology 2 domain containing transforming protein D, b; src homology 2 domain containing transforming protein D, b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045077.2 → NP_001038542.1  Src homology 2 domain containing transforming protein D, b

      See identical proteins and their annotated locations for NP_001038542.1

      Status: PROVISIONAL

      Source sequence(s)
      BX470234, BX470239
      UniProtKB/TrEMBL
      Q08BY4, Q1LX13
      Conserved Domains (1) summary
      cd09945
      Location:289 → 386
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      21398507..21471107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469342.2 → XP_021325017.1  src homology 2 domain containing transforming protein D, b isoform X1

      UniProtKB/TrEMBL
      A0A8M3AMA3
      Conserved Domains (1) summary
      cd09945
      Location:315 → 412
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    2. XM_009296270.4 → XP_009294545.1  src homology 2 domain containing transforming protein D, b isoform X1

      UniProtKB/TrEMBL
      A0A8M3AMA3
      Conserved Domains (1) summary
      cd09945
      Location:315 → 412
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    3. XM_005170476.5 → XP_005170533.1  src homology 2 domain containing transforming protein D, b isoform X2

      See identical proteins and their annotated locations for XP_005170533.1

      UniProtKB/TrEMBL
      Q08BY4, Q1LX13
      Related
      ENSDARP00000083841.5, ENSDART00000089408.6
      Conserved Domains (1) summary
      cd09945
      Location:289 → 386
      SH2_SHB_SHD_SHE_SHF_like; Src homology 2 domain found in SH2 domain-containing adapter proteins B, D, E, and F (SHB, SHD, SHE, SHF)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395104.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      104170..167880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077367.1: Suppressed sequence

      Description
      NM_001077367.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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