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    otulinb OTU deubiquitinase with linear linkage specificity b [ Danio rerio (zebrafish) ]

    Gene ID: 100005714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    otulinbprovided by ZNC
    Official Full Name
    OTU deubiquitinase with linear linkage specificity bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-627
    See related
    Ensembl:ENSDARG00000079886 AllianceGenome:ZFIN:ZDB-GENE-070912-627
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam105bb; wu:fc69a03; si:dkeyp-106c5.3
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See otulinb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31942391..31952001)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31959157..31969085)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma variable 2 Neighboring gene amphiphysin Neighboring gene ANKH inorganic pyrophosphate transport regulator b Neighboring gene MYC proto-oncogene, bHLH transcription factor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Marandel L, et al. Mol Reprod Dev, 2012 Feb. PMID 22213278
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin thioesterase otulin
    Names
    family with sequence similarity 105, member B
    NP_001159487.1
    XP_005163523.1
    XP_005163524.1
    XP_005163525.1
    XP_005163526.1
    XP_005163527.1
    XP_005163528.1
    XP_009296871.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166015.1 → NP_001159487.1  ubiquitin thioesterase otulin

      See identical proteins and their annotated locations for NP_001159487.1

      Status: PROVISIONAL

      Source sequence(s)
      CR391940
      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Related
      ENSDARP00000113277.1, ENSDART00000146758.3
      Conserved Domains (1) summary
      pfam16218
      Location:121 → 380
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31942391..31952001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163467.5 → XP_005163524.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163524.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121 → 380
      Peptidase_C101; Peptidase family C101

    2. XM_005163471.4 → XP_005163528.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163528.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Related
      ENSDART00000133182.3
      Conserved Domains (1) summary
      pfam16218
      Location:61 → 320
      Peptidase_C101; Peptidase family C101

    3. XM_005163468.5 → XP_005163525.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163525.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121 → 380
      Peptidase_C101; Peptidase family C101

    4. XM_005163470.5 → XP_005163527.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163527.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Conserved Domains (1) summary
      pfam16218
      Location:61 → 320
      Peptidase_C101; Peptidase family C101

    5. XM_005163466.5 → XP_005163523.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163523.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121 → 380
      Peptidase_C101; Peptidase family C101

    6. XM_009298596.4 → XP_009296871.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_009296871.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Conserved Domains (1) summary
      pfam16218
      Location:61 → 320
      Peptidase_C101; Peptidase family C101

    7. XM_005163469.4 → XP_005163526.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163526.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Related
      ENSDART00000132113.3
      Conserved Domains (1) summary
      pfam16218
      Location:61 → 320
      Peptidase_C101; Peptidase family C101
    Nucleotide Protein
    Heading Accession and Version

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