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    synrg synergin, gamma [ Danio rerio (zebrafish) ]

    Gene ID: 555257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    synrgprovided by ZNC
    Official Full Name
    synergin, gammaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9396
    See related
    Ensembl:ENSDARG00000073926 AllianceGenome:ZFIN:ZDB-GENE-030131-9396
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj67h08; wu:fj67h08
    Summary
    Predicted to be part of clathrin coat of trans-Golgi network vesicle. Orthologous to human SYNRG (synergin gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See synrg in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (15886064..15983188, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (15950042..16047173, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 2A Neighboring gene dual specificity phosphatase 14 Neighboring gene uncharacterized LOC137487733 Neighboring gene HNF1 homeobox Ba Neighboring gene dynein, light chain, LC8-type 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Feng L, et al. Dev Biol, 2010 Feb 1. PMID 19874812, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    part_of clathrin coat of trans-Golgi network vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synergin gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      15886064..15983188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157442.5 → XP_005157499.1  synergin gamma isoform X7

      UniProtKB/TrEMBL
      A0A8M2B3J5
      Conserved Domains (4) summary
      cd00052
      Location:206 → 274
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam05819
      Location:892 → 1011
      NolX; NolX protein
      pfam09606
      Location:40 → 341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:233 → 542
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. XM_068213691.1 → XP_068069792.1  synergin gamma isoform X5

    3. XM_068213692.1 → XP_068069793.1  synergin gamma isoform X6

    4. XM_005157441.5 → XP_005157498.1  synergin gamma isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q1R4
      Conserved Domains (4) summary
      cd00052
      Location:306 → 374
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26386
      Location:333 → 642
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    5. XM_005157440.5 → XP_005157497.1  synergin gamma isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q5G9
      Related
      ENSDARP00000130488.2, ENSDART00000166583.2
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    6. XM_009291573.4 → XP_009289848.1  synergin gamma isoform X2

      UniProtKB/TrEMBL
      A0A8M3B0W7
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    7. XM_005157439.5 → XP_005157496.1  synergin gamma isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3R6, E7F371
      Related
      ENSDARP00000102639.2, ENSDART00000115129.5
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    8. XM_003200027.6 → XP_003200075.2  synergin gamma isoform X8

      UniProtKB/TrEMBL
      A0A8M9PUQ3
      Conserved Domains (4) summary
      cd00052
      Location:206 → 274
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam05819
      Location:892 → 1011
      NolX; NolX protein
      pfam09606
      Location:40 → 341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:233 → 542
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394941.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      210913..307603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472922.2 → XP_021328597.1  synergin gamma isoform X7

      UniProtKB/TrEMBL
      A0A8M2B3J5
      Conserved Domains (4) summary
      cd00052
      Location:206 → 274
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam05819
      Location:892 → 1011
      NolX; NolX protein
      pfam09606
      Location:40 → 341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:233 → 542
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. XM_068218788.1 → XP_068074889.1  synergin gamma isoform X5

    3. XM_021472921.2 → XP_021328596.1  synergin gamma isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q1R4
      Conserved Domains (4) summary
      cd00052
      Location:306 → 374
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26386
      Location:333 → 642
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    4. XM_021472920.2 → XP_021328595.1  synergin gamma isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q5G9
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    5. XM_021472918.2 → XP_021328593.1  synergin gamma isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3R6, E7F371
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    6. XM_021472924.2 → XP_021328599.1  synergin gamma isoform X8

      UniProtKB/TrEMBL
      A0A8M9PUQ3
      Conserved Domains (4) summary
      cd00052
      Location:206 → 274
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam05819
      Location:892 → 1011
      NolX; NolX protein
      pfam09606
      Location:40 → 341
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl26386
      Location:233 → 542
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    7. XM_021472919.2 → XP_021328594.1  synergin gamma isoform X2

      UniProtKB/TrEMBL
      A0A8M3B0W7
      Conserved Domains (4) summary
      cd00052
      Location:398 → 466
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:40 → 119
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25549
      Location:102 → 135
      ARGLU; Arginine and glutamate-rich 1
      cl26464
      Location:173 → 704
      Atrophin-1; Atrophin-1 family

    8. XM_068218787.1 → XP_068074888.1  synergin gamma isoform X9

    Nucleotide Protein
    Heading Accession and Version

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