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    ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 322060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ywhae1provided by ZNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-779
    See related
    Ensembl:ENSDARG00000006399 AllianceGenome:ZFIN:ZDB-GENE-030131-779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ywhae; fe38c12; zgc:55377; zgc:77062; wu:fb48f06; wu:fe38c12; wu:fi22e10
    Summary
    Predicted to enable phosphoserine residue binding activity. Predicted to be involved in protein localization; regulation of mitotic cell cycle; and signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; otic vesicle; post-vent region; and tail bud. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ywhae1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (24746440..24755108)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (24811175..24819843)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75A Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene carboxypeptidase D, a Neighboring gene golgi SNAP receptor complex member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. Antón-Galindo E, et al. Mol Psychiatry, 2022 Sep. PMID 35501409
    2. Neuroprotective effects of nanogold-based Ayurveda medicine Suvarna Bhasma against rotenone-induced Parkinson's-like model. Biswas S, et al. J Ayurveda Integr Med, 2024 Jan-Feb. PMID 38145607, Free PMC Article
    3. Characterization of Hspb8 in Zebrafish. Dubińska-Magiera M, et al. Cells, 2020 Jun 26. PMID 32604890, Free PMC Article
    4. Expression analysis of the family of 14-3-3 proteins in zebrafish development. Besser J, et al. Gene Expr Patterns, 2007 Feb. PMID 17127101
    5. Effects of chronic tramadol exposure on the zebrafish brain: a proteomic study. Zhuo HQ, et al. J Proteomics, 2012 Jun 18. PMID 22507199

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoserine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
    Names
    14-3-3 epsilon
    14-3-3 protein epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212605.2 → NP_997770.1  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1

      See identical proteins and their annotated locations for NP_997770.1

      Status: VALIDATED

      Source sequence(s)
      BC160627, CR524483
      UniProtKB/TrEMBL
      A0A2R8QM74, F6NZM7, Q7ZW20
      Related
      ENSDARP00000032575.5, ENSDART00000032306.7
      Conserved Domains (1) summary
      cd10020
      Location:4 → 233
      14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      24746440..24755108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481333.2 → XP_021337008.1  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBU3
      Conserved Domains (1) summary
      cd10020
      Location:4 → 233
      14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394947.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      505678..514346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395323.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      97469..106137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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