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    dlg5a discs, large homolog 5a (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 569065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dlg5aprovided by ZNC
    Official Full Name
    discs, large homolog 5a (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3149
    See related
    Ensembl:ENSDARG00000074059 AllianceGenome:ZFIN:ZDB-GENE-030131-3149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dlg5; wu:fc28f03
    Summary
    Predicted to be involved in negative regulation of hippo signaling. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in membrane. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dlg5a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (16342486..16497065)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (16210938..16366073)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene annexin A11a Neighboring gene molybdenum cofactor sulfurase Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1a Neighboring gene uncharacterized LOC137487382 Neighboring gene leucine rich melanocyte differentiation associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cytoskeletal Keratins Are Overexpressed in a Zebrafish Model of Idiopathic Scoliosis. Cuevas M, et al. Genes (Basel), 2023 May 9. PMID 37239418, Free PMC Article
    2. Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Terhune EA, et al. Hum Mutat, 2021 Apr. PMID 33382518, Free PMC Article
    3. A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Gordon PM, et al. Nat Commun, 2021 Mar 26. PMID 33771997, Free PMC Article
    4. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
    5. Statistical evidence for a more than 800-million-year-old evolutionarily conserved genomic region in our genome. Danchin EG, et al. J Mol Evol, 2004 Nov. PMID 15693615

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disks large homolog 5a
    Names
    discs, large homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145603.1 → NP_001139075.1  disks large homolog 5a

      Status: PROVISIONAL

      Source sequence(s)
      AL645926, BX323467, BX323798
      UniProtKB/TrEMBL
      A0A8M1NT87, A0A8M2B3F6, B7ZC95, E7EXQ0
      Related
      ENSDARP00000096269.4, ENSDART00000105496.5
      Conserved Domains (11) summary
      cd11860
      Location:1604 → 1666
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00228
      Location:1346 → 1428
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:673 → 760
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01671
      Location:9 → 88
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam00625
      Location:1745 → 1914
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:105 → 188
      Takusan; Takusan
      pfam05276
      Location:421 → 625
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
      pfam09728
      Location:272 → 604
      Taxilin; Myosin-like coiled-coil protein
      pfam16610
      Location:1426 → 1506
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl17190
      Location:1759 → 1915
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl23720
      Location:315 → 437
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      16342486..16497065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212911.1 → XP_068069012.1  disks large homolog 5a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3F6, E7EXQ0

    2. XM_068212910.1 → XP_068069011.1  disks large homolog 5a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3F6, E7EXQ0

    3. XM_005156681.5 → XP_005156738.1  disks large homolog 5a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B3F6, A0A8M2B3K9, E7EXQ0
      Related
      ENSDARP00000111982.1, ENSDART00000124710.4
      Conserved Domains (11) summary
      cd11860
      Location:1639 → 1701
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00228
      Location:1381 → 1463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:696 → 783
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01671
      Location:9 → 88
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam00625
      Location:1780 → 1949
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:128 → 211
      Takusan; Takusan
      pfam05276
      Location:444 → 648
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
      pfam09728
      Location:295 → 627
      Taxilin; Myosin-like coiled-coil protein
      pfam16610
      Location:1461 → 1541
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl17190
      Location:1794 → 1950
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl23720
      Location:338 → 460
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. XM_068212912.1 → XP_068069013.1  disks large homolog 5a isoform X3

      UniProtKB/TrEMBL
      A0A8M3BEL3
    Nucleotide Protein Strain
    Heading Accession and Version

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