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    ide insulin-degrading enzyme [ Danio rerio (zebrafish) ]

    Gene ID: 561390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ideprovided by ZNC
    Official Full Name
    insulin-degrading enzymeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-85
    See related
    Ensembl:ENSDARG00000075570 AllianceGenome:ZFIN:ZDB-GENE-070410-85
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162603
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ide in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (42309580..42353427)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (42183506..42226316)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kynurenine 3-monooxygenase Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene membrane-associated ring finger (C3HC4) 5 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene BTAF1 RNA polymerase II, B-TFIID transcription factor-associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Thifluzamide affects lipid metabolism in zebrafish (Danio reio). Yang Y, et al. Sci Total Environ, 2018 Aug 15. PMID 29758875
    2. Altered glycometabolism in zebrafish exposed to thifluzamide. Yang Y, et al. Chemosphere, 2017 Sep. PMID 28535465
    3. Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Qian L, et al. Environ Pollut, 2019 Apr. PMID 30721868
    4. Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Nagayoshi S, et al. Development, 2008 Jan. PMID 18065431
    5. Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Cui Y, et al. Hum Exp Toxicol, 2017 Mar. PMID 27193966

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC162603

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pancreas regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulin-degrading enzyme
    Names
    insulysin
    NP_001082994.2
    XP_005169585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089525.2 → NP_001082994.2  insulin-degrading enzyme

      Status: VALIDATED

      Source sequence(s)
      BX005050
      UniProtKB/TrEMBL
      A0A0R4IL71, A4QP10, B8JI45
      Related
      ENSDARP00000135107.1, ENSDART00000158367.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      42309580..42353427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169528.5 → XP_005169585.1  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGX2, A4QP10
      Conserved Domains (4) summary
      COG1025
      Location:24 → 939
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:53 → 191
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:217 → 395
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:401 → 682
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    Nucleotide Protein Strain
    Heading Accession and Version

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