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    ncoa4 nuclear receptor coactivator 4 [ Danio rerio (zebrafish) ]

    Gene ID: 394104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncoa4provided by ZNC
    Official Full Name
    nuclear receptor coactivator 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-689
    See related
    Ensembl:ENSDARG00000021439 AllianceGenome:ZFIN:ZDB-GENE-040426-689
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55307; zgc:77270
    Summary
    Predicted to enable transcription coactivator activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in several cellular components, including chromosome; cytoplasmic vesicle; and vacuole. Is expressed in digestive system and hematopoietic system. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ncoa4 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (3915260..3936555, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (3784664..3805959, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 883 Neighboring gene translocase of inner mitochondrial membrane 23 homolog b (yeast) Neighboring gene uncharacterized LOC137487354 Neighboring gene Yip1 domain family, member 3 Neighboring gene leucine rich repeat containing 73

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Mancias JD, et al. Elife, 2015 Oct 5. PMID 26436293, Free PMC Article
    2. Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. Liu Q, et al. FASEB J, 2023 May. PMID 37043308
    3. Combinatorial regulation of novel erythroid gene expression in zebrafish. Galloway JL, et al. Exp Hematol, 2008 Apr. PMID 18243489, Free PMC Article
    4. RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Li Z, et al. J Appl Toxicol, 2016 Jan. PMID 26011545
    5. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. Zheng D, et al. BMC Genomics, 2010 Oct 11. PMID 20937081, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55307

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in autolysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201129.1 → NP_957423.1  nuclear receptor coactivator 4

      Status: PROVISIONAL

      Source sequence(s)
      BC047166
      UniProtKB/Swiss-Prot
      A0A8M2B394, Q6P0F7, Q802X2
      Related
      ENSDARP00000013664.7, ENSDART00000017052.9
      Conserved Domains (1) summary
      pfam12489
      Location:33 → 161
      ARA70; Nuclear coactivator

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      3915260..3936555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156494.5 → XP_005156551.1  nuclear receptor coactivator 4 isoform X1

      Conserved Domains (1) summary
      pfam12489
      Location:33 → 161
      ARA70; Nuclear coactivator
    Nucleotide Protein Strain
    Heading Accession and Version

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