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    myo18aa myosin XVIIIAa [ Danio rerio (zebrafish) ]

    Gene ID: 566880, updated on 4-Jan-2025

    Summary

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    Official Symbol
    myo18aaprovided by ZNC
    Official Full Name
    myosin XVIIIAaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080425-5
    See related
    Ensembl:ENSDARG00000075752 AllianceGenome:ZFIN:ZDB-GENE-080425-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myo18l2
    Summary
    Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Acts upstream of or within Golgi organization; cell-matrix adhesion; and striated muscle cell development. Predicted to be part of myosin complex. Is expressed in somite border. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See myo18aa in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36950774..37075320, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (37006267..37131623, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 12a Neighboring gene seizure related 6 homolog a Neighboring gene vascular endothelial zinc finger 1a Neighboring gene CUE domain containing 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myo18b is essential for sarcomere assembly in fast skeletal muscle. Berger J, et al. Hum Mol Genet, 2017 Mar 15. PMID 28104788
    2. The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish. Cao J, et al. J Genet Genomics, 2014 Aug 20. PMID 25160974
    3. Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Cao JM, et al. Sci Rep, 2016 Nov 8. PMID 27824130, Free PMC Article
    4. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Full loss of myo18b function results in a complete lack of sarcomeric structure, revealing a highly surprising and essential role for myo18b in sarcomere assembly. Importantly, scattered thin and thick filaments assemble throughout the sarcoplasm. These observations suggest a novel model of sarcomere assembly where Myo18b coordinates the integration of preformed thick and thin filaments into the sarcomere
      Title: Myo18b is essential for sarcomere assembly in fast skeletal muscle.
    2. MYO18A likely functions in the adhesion process that maintains the stable attachment of myofibers to ECM (extracellular matrix) and muscle integrity during early development
      Title: The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin XVIIIAa; unconventional myosin-XVIIIa
    Names
    myo18b
    myosin XVIII-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      36950774..37075320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223999.1 → XP_068080100.1  unconventional myosin-XVIIIa isoform X6

      UniProtKB/TrEMBL
      A0A0R4J7R2, A0A8N7T868
      Related
      ENSDARP00000118849.2, ENSDART00000132023.3

    2. XM_068223998.1 → XP_068080099.1  unconventional myosin-XVIIIa isoform X5

      UniProtKB/TrEMBL
      A0A0R4J7R2, A0A8N7T868

    3. XM_068223994.1 → XP_068080095.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8M3AX53, A0A8M9QL86

    4. XM_068223997.1 → XP_068080098.1  unconventional myosin-XVIIIa isoform X4

      UniProtKB/TrEMBL
      A0A8M9PUB6

    5. XM_068223996.1 → XP_068080097.1  unconventional myosin-XVIIIa isoform X3

      UniProtKB/TrEMBL
      A0A8M9QH80

    6. XM_068224002.1 → XP_068080103.1  unconventional myosin-XVIIIa isoform X9

      UniProtKB/TrEMBL
      A0A8M9QCN6

    7. XM_068223995.1 → XP_068080096.1  unconventional myosin-XVIIIa isoform X2

      UniProtKB/TrEMBL
      A0A8M3BDA6

    8. XM_068224001.1 → XP_068080102.1  unconventional myosin-XVIIIa isoform X8

      UniProtKB/TrEMBL
      A0A8M3AX31

    9. XM_068223993.1 → XP_068080094.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8M3AX53, A0A8M9QL86

    10. XM_068224000.1 → XP_068080101.1  unconventional myosin-XVIIIa isoform X7

      UniProtKB/TrEMBL
      A0A8M9Q6N9
    Nucleotide Protein Strain
    Heading Accession and Version

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