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    spry2 sprouty RTK signaling antagonist 2 [ Danio rerio (zebrafish) ]

    Gene ID: 335098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spry2provided by ZNC
    Official Full Name
    sprouty RTK signaling antagonist 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7038
    See related
    Ensembl:ENSDARG00000078308 AllianceGenome:ZFIN:ZDB-GENE-030131-7038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk66h11; wu:fk93e11; zgc:110440
    Summary
    Acts upstream of or within blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See spry2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (5273494..5277583)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (4557477..4561653)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene SLIT and NTRK like family member 1 Neighboring gene uncharacterized LOC101882161 Neighboring gene Nedd4 family interacting protein 2 Neighboring gene tubulin, alpha 8 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Harish RK, et al. Development, 2023 Oct 1. PMID 37665167, Free PMC Article
    2. Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Yu SR, et al. Nature, 2009 Sep 24. PMID 19741606
    3. miR-27b controls venous specification and tip cell fate. Biyashev D, et al. Blood, 2012 Mar 15. PMID 22207734, Free PMC Article
    4. Cost-precision trade-off relation determines the optimal morphogen gradient for accurate biological pattern formation. Song Y, et al. Elife, 2021 Aug 17. PMID 34402427, Free PMC Article
    5. miR-27a/b is a posttranscriptional regulator of Gpr126 (Adgrg6). Musa G, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31596512

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within venous blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein sprouty homolog 2
    Names
    sprouty homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003842.2 → NP_001003842.2  protein sprouty homolog 2

      See identical proteins and their annotated locations for NP_001003842.2

      Status: PROVISIONAL

      Source sequence(s)
      BC095266
      UniProtKB/TrEMBL
      Q4VBS7
      Related
      ENSDARP00000151098.1, ENSDART00000189676.1
      Conserved Domains (1) summary
      pfam05210
      Location:185 → 281
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      5273494..5277583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160285.5 → XP_005160342.1  protein sprouty homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B743, F1QU39
      Related
      ENSDARP00000052422.4, ENSDART00000052423.6
      Conserved Domains (1) summary
      pfam05210
      Location:185 → 281
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein Strain
    Heading Accession and Version

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