KRT73 keratin 73 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KRT73provided by HGNC
Official Full Name: keratin 73provided by HGNC
Primary source: HGNC:HGNC:28928
See related: Ensembl:ENSG00000186049 MIM:608247; AllianceGenome:HGNC:28928
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K73; CK-73; K6IRS3; IRT6IRS3; KRT6IRS3
Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression: Biased expression in skin (RPKM 2.3), lymph node (RPKM 0.7) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (52607570..52630761, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (52572166..52596120, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (53001354..53012343, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report on the cloning of two novel human type II keratin cDNAs, K6irs3 and K6irs4, which were specifically expressed in the inner root sheath of the hair follicle
Title: K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-57111 (e-PCR)
- UniSTS:47005

NoName (e-PCR)
- UniSTS:481491

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: keratin, type II cytoskeletal 73

Names: cytokeratin-73; keratin 6 irs3; keratin 73, type II; type II inner root sheath-specific keratin-K6irs3; type-II keratin Kb36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012319.1 RefSeqGene

Range

5001..15990

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_175068.3 → NP_778238.1 keratin, type II cytoskeletal 73

See identical proteins and their annotated locations for NP_778238.1

Status: REVIEWED

Source sequence(s)

AJ508776

Consensus CDS

CCDS8834.1

UniProtKB/Swiss-Prot

Q32MB2, Q86Y46

Related

ENSP00000307014.3, ENST00000305748.7

Conserved Domains (4) summary

pfam00038
Location:131 → 444

Filament; Intermediate filament protein

pfam16208
Location:16 → 128

Keratin_2_head; Keratin type II head

cl01503
Location:10 → 93

TrbL; TrbL/VirB6 plasmid conjugal transfer protein

cl09176
Location:298 → 429

FlgN; FlgN protein