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    lmnb1 lamin B1 [ Danio rerio (zebrafish) ]

    Gene ID: 195816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmnb1provided by ZNC
    Official Full Name
    lamin B1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020424-2
    See related
    Ensembl:ENSDARG00000044299 AllianceGenome:ZFIN:ZDB-GENE-020424-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc06g01; wu:fc06g01
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lmnb1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (16036249..16056908)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (16078091..16098789)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 7 family, member A1 Neighboring gene phosphorylated adaptor for RNA export Neighboring gene si:dkey-184a18.5 Neighboring gene multiple EGF-like-domains 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A CRISPR/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy. Nicolas HA, et al. Dev Dyn, 2022 Apr. PMID 34599606
    2. Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish. Chen ZL, et al. Exp Gerontol, 2023 Sep. PMID 37482108
    3. Transgenic strategies to generate heterogeneous hepatic cancer models in zebrafish. Fei F, et al. J Mol Cell Biol, 2019 Dec 23. PMID 31370058, Free PMC Article
    4. Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis. Ye L, et al. Development, 2015 Apr 15. PMID 25852199, Free PMC Article
    5. Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Falisse E, et al. Aquat Toxicol, 2017 Aug. PMID 28605648

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lamin-B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152972.2 → NP_694504.2  lamin-B1

      See identical proteins and their annotated locations for NP_694504.2

      Status: PROVISIONAL

      Source sequence(s)
      BC044402
      UniProtKB/TrEMBL
      Q803N8
      Related
      ENSDARP00000065036.3, ENSDART00000065037.4
      Conserved Domains (2) summary
      pfam00038
      Location:32 → 388
      Filament; Intermediate filament protein
      pfam00932
      Location:436 → 544
      LTD; Lamin Tail Domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      16036249..16056908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155556.5 → XP_005155613.1  lamin-B1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B213, F1QHC4
      Related
      ENSDARP00000153143.1, ENSDART00000188757.1
      Conserved Domains (2) summary
      pfam00038
      Location:32 → 388
      Filament; Intermediate filament protein
      pfam00932
      Location:436 → 544
      LTD; Lamin Tail Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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