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    Ei24 EI24, autophagy associated transmembrane protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ei24provided by RGD
    Official Full Name
    EI24, autophagy associated transmembrane proteinprovided by RGD
    Primary source
    RGD:1309868
    See related
    EnsemblRapid:ENSRNOG00000030391 AllianceGenome:RGD:1309868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable importin-alpha family protein binding activity. Predicted to be involved in macroautophagy. Predicted to act upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 381.9), Adrenal (RPKM 232.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ei24 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44683138..44699502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36494289..36510653, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39254883..39271238, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene 60S ribosomal protein L14 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. Yuan L, et al. J Biol Chem, 2018 Jun 29. PMID 29769309, Free PMC Article
    2. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. Zhao YG, et al. J Biol Chem, 2012 Dec 7. PMID 23074225, Free PMC Article
    3. Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide. Mork CN, et al. FEBS Lett, 2007 Nov 27. PMID 17981155, Free PMC Article
    4. The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain. Lieu KG, et al. J Cell Biol, 2014 May 12. PMID 24821838, Free PMC Article
    5. Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. Sung YH, et al. J Biol Chem, 2013 Oct 25. PMID 24014029, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic beta-cell survival
      Title: Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112713

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    etoposide-induced protein 2.4 homolog
    Names
    etoposide induced 2.4 mRNA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025660.2 → NP_001020831.1  etoposide-induced protein 2.4 homolog

      See identical proteins and their annotated locations for NP_001020831.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7
      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)

    2. NM_001433200.1 → NP_001420129.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    3. NM_001433201.1 → NP_001420130.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    4. NM_001433202.1 → NP_001420131.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    5. NM_001433208.1 → NP_001420137.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    6. NM_001433209.1 → NP_001420138.1  etoposide-induced protein 2.4 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4KM77
      UniProtKB/TrEMBL
      A0A8L2QNF3, A6KRM7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      44683138..44699502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242800.5 → XP_006242862.1  etoposide-induced protein 2.4 homolog isoform X1

      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)

    2. XM_006242801.5 → XP_006242863.1  etoposide-induced protein 2.4 homolog isoform X1

      Related
      ENSRNOP00000042710.5, ENSRNOT00000046590.6
      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)

    3. XM_039081024.2 → XP_038936952.1  etoposide-induced protein 2.4 homolog isoform X1

      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM77.1 GenPept UniProtKB/Swiss-Prot:Q4KM77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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