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    Vstm2a V-set and transmembrane domain containing 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689106, updated on 27-Dec-2024

    Summary

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    Symbol
    Vstm2aprovided by RGD
    Full Name
    V-set and transmembrane domain containing 2Aprovided by RGD
    Primary source
    RGD:1596197
    See related
    EnsemblRapid:ENSRNOG00000005180 AllianceGenome:RGD:1596197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cellular response to BMP stimulus; positive regulation of brown fat cell differentiation; and positive regulation of white fat cell proliferation. Predicted to be located in extracellular region. Predicted to be active in membrane. Orthologous to human VSTM2A (V-set and transmembrane domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 173.9) and Uterus (RPKM 75.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vstm2a in Genome Data Viewer
    Location:
    14q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (94873259..95117189)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (90660012..90897561)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (99528996..99558304)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481787 Neighboring gene COP9 signalosome complex subunit 8-like Neighboring gene calcium regulated heat stable protein 1, pseudogene 1 Neighboring gene Sec61 translocon subunit gamma Neighboring gene epidermal growth factor receptor Neighboring gene uncharacterized LOC134481789

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Amplification of Adipogenic Commitment by VSTM2A. Secco B, et al. Cell Rep, 2017 Jan 3. PMID 28052263, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of white fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    V-set and transmembrane domain containing 2A; V-set and transmembrane domain-containing protein 2A
    Names
    V-set and transmembrane domain-containing protein 2A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432988.1 → NP_001419917.1  V-set and transmembrane domain containing 2A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JPX2, A6JPX3

    2. NM_001432989.1 → NP_001419918.1  V-set and transmembrane domain containing 2A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JPX2, D3ZM70

    3. NM_001432990.1 → NP_001419919.1  V-set and transmembrane domain containing 2A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JPX2

    4. NM_001432991.1 → NP_001419920.1  V-set and transmembrane domain containing 2A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JPX2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      94873259..95117189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092861.2 → XP_038948789.1  V-set and transmembrane domain-containing protein 2A isoform X1

      Conserved Domains (1) summary
      smart00409
      Location:33 → 148
      IG; Immunoglobulin

    2. XM_039092862.2 → XP_038948790.1  V-set and transmembrane domain-containing protein 2A isoform X2

      UniProtKB/TrEMBL
      A6JPX2
      Conserved Domains (1) summary
      smart00409
      Location:33 → 148
      IG; Immunoglobulin

    3. XM_063273792.1 → XP_063129862.1  V-set and transmembrane domain-containing protein 2A isoform X7

      UniProtKB/TrEMBL
      A6JPX2

    4. XM_063273791.1 → XP_063129861.1  V-set and transmembrane domain-containing protein 2A isoform X6

      UniProtKB/TrEMBL
      A6JPX2

    5. XM_039092865.2 → XP_038948793.1  V-set and transmembrane domain-containing protein 2A isoform X4

      Conserved Domains (1) summary
      smart00409
      Location:33 → 148
      IG; Immunoglobulin

    6. XM_039092863.2 → XP_038948791.1  V-set and transmembrane domain-containing protein 2A isoform X3

      Conserved Domains (1) summary
      smart00409
      Location:33 → 148
      IG; Immunoglobulin

    7. XM_039092866.2 → XP_038948794.1  V-set and transmembrane domain-containing protein 2A isoform X5

      Related
      ENSRNOP00000006897.8, ENSRNOT00000006897.9
      Conserved Domains (1) summary
      smart00409
      Location:33 → 148
      IG; Immunoglobulin

    8. XM_063273794.1 → XP_063129864.1  V-set and transmembrane domain-containing protein 2A isoform X10

    9. XM_063273793.1 → XP_063129863.1  V-set and transmembrane domain-containing protein 2A isoform X9

    10. XM_039092867.2 → XP_038948795.1  V-set and transmembrane domain-containing protein 2A isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:34 → 83
      IG; Immunoglobulin
    Nucleotide Protein Strain
    Heading Accession and Version

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