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    Cryba2 crystallin, beta A2 [ Mus musculus (house mouse) ]

    Gene ID: 12958, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cryba2provided by MGI
    Official Full Name
    crystallin, beta A2provided by MGI
    Primary source
    MGI:MGI:104336
    See related
    Ensembl:ENSMUSG00000006546 AllianceGenome:MGI:104336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130107M19Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within lens development in camera-type eye. Is expressed in brain; eye; gut gland; and pancreas primordium. Human ortholog(s) of this gene implicated in cataract 42. Orthologous to human CRYBA2 (crystallin beta A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Cryba2 in Genome Data Viewer
    Location:
    1 C4; 1 38.54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74929093..74938001, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74889934..74898842, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16582 Neighboring gene cyclin dependent kinase 5, regulatory subunit 2 Neighboring gene FEV transcription factor, ETS family member Neighboring gene microRNA 375 Neighboring gene cilia and flagella associated protein 65

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    beta-crystallin A2
    Names
    beta-A2 crystallin
    betaA2-crystallin
    lens structural protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431816.1NP_001418745.1  beta-crystallin A2

      Status: VALIDATED

      Source sequence(s)
      AC139023
      UniProtKB/Swiss-Prot
      Q540J7, Q9JJV1
    2. NM_021541.4NP_067516.1  beta-crystallin A2

      See identical proteins and their annotated locations for NP_067516.1

      Status: VALIDATED

      Source sequence(s)
      AC139023
      Consensus CDS
      CCDS15059.1
      UniProtKB/Swiss-Prot
      Q540J7, Q9JJV1
      Related
      ENSMUSP00000006721.3, ENSMUST00000006721.3
      Conserved Domains (1) summary
      pfam00030
      Location:1498
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74929093..74938001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495656.3XP_006495719.1  beta-crystallin A2 isoform X1

      Conserved Domains (1) summary
      pfam00030
      Location:1498
      Crystall; Beta/Gamma crystallin