MYO1B myosin IB [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYO1Bprovided by HGNC
Official Full Name: myosin IBprovided by HGNC
Primary source: HGNC:HGNC:7596
See related: Ensembl:ENSG00000128641 MIM:606537; AllianceGenome:HGNC:7596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MMIa; myr1; MYH-1c; MMI-alpha
Summary: Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Involved in actin filament organization and post-Golgi vesicle-mediated transport. Located in several cellular components, including actin filament; endosome; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver (RPKM 53.1), lung (RPKM 45.2) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q32.3

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (191245404..191425386)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (191734489..191914303)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (192110130..192290112)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma.
Title: CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma.
MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma.
Title: MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma.
Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
Title: Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1alpha in colorectal cancer.
Title: Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1α in colorectal cancer.
Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma.
Title: Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma.
F-actin depolymerizes when sliding on immobilized Myo1b.
Title: Myosin 1b is an actin depolymerase.
identify SRSF1 as an important oncodriver that integrates AS control of MYO1B into promotion of gliomagenesis and represents a potential prognostic biomarker and target for glioma therapy.
Title: Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B.
The authors report here the identification of a novel Toxoplasma effector protein that is exported from the parasitophorous vacuole in a MYR1-dependent manner and localizes to the host's nucleus. Parasites lacking this inducer of host cyclin E (HCE1) are unable to modulate E2F transcription factor target genes, including cyclin E, and exhibit a substantial growth defect.
Title: Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1.
Data suggested a potential role of Myo1b in cervical carcinogenesis and tumor progression and provided novel insights into the mechanism of how this factor promotes cell proliferation, migration, and invasion in CC cells.
Title: Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Data demonstrated that the passenger strand of miR145 acted as an antitumor miRNA through targeting MYO1B in HNSCC cells. The involvement of dual strands of premiR145 (miR1455p and miR1453p) in the regulation of HNSCC pathogenesis is a novel concept in present RNA research.
Title: Passenger strand of miR-145-3p acts as a tumor-suppressor by targeting MYO1B in head and neck squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009P46 (e-PCR)
- UniSTS:61703

RH122923 (e-PCR)
- UniSTS:135220

G32756 (e-PCR)
- UniSTS:117337

SHGC-33894 (e-PCR)
- UniSTS:17005

SHGC-36003 (e-PCR)
- UniSTS:6777

RH70476 (e-PCR)
- UniSTS:386

RH69381 (e-PCR)
- UniSTS:41383

G09498 (e-PCR)
- UniSTS:69307

MYO1B__6193 (e-PCR)
- UniSTS:464069

RH66000 (e-PCR)
- UniSTS:83160

SHGC-112645 (e-PCR)
- UniSTS:168671

RH122853 (e-PCR)
- UniSTS:135151

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Ib

Names: MYO1B variant protein; myosin-I alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130158.3 → NP_001123630.1 unconventional myosin-Ib isoform 1

See identical proteins and their annotated locations for NP_001123630.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949, DB461518

Consensus CDS

CCDS46477.1

UniProtKB/Swiss-Prot

O43794, O43795, Q7Z6L5

UniProtKB/TrEMBL

B0I1S9

Related

ENSP00000376132.3, ENST00000392318.8

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001161819.3 → NP_001155291.1 unconventional myosin-Ib isoform 1

See identical proteins and their annotated locations for NP_001155291.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AB290176, AI751497, AJ001381, BC053558, BC060849, BF061446, BQ027157, CN295039

Consensus CDS

CCDS46477.1

UniProtKB/Swiss-Prot

O43794, O43795, Q7Z6L5

UniProtKB/TrEMBL

B0I1S9

Related

ENSP00000306382.4, ENST00000304164.8

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001330237.2 → NP_001317166.1 unconventional myosin-Ib isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC068056, AC092614, AC133534

Consensus CDS

CCDS82546.1

UniProtKB/TrEMBL

E9PDF6

Related

ENSP00000376130.1, ENST00000392316.5

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:912 → 1089

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001330238.2 → NP_001317167.1 unconventional myosin-Ib isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AC068056, AC092614, AC133534

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:912 → 1089

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_012223.5 → NP_036355.2 unconventional myosin-Ib isoform 2

See identical proteins and their annotated locations for NP_036355.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949

Consensus CDS

CCDS2311.1

UniProtKB/Swiss-Prot

O43795

UniProtKB/TrEMBL

B0I1S9

Related

ENSP00000341903.4, ENST00000339514.8

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:883 → 1060

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

191245404..191425386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047444410.1 → XP_047300366.1 unconventional myosin-Ib isoform X1
XM_047444412.1 → XP_047300368.1 unconventional myosin-Ib isoform X4
XM_024452914.2 → XP_024308682.1 unconventional myosin-Ib isoform X3

Conserved Domains (3) summary

smart00015
Location:769 → 791

IQ; Calmodulin-binding motif

cd01378
Location:49 → 708

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:932 → 1107

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_024452915.2 → XP_024308683.1 unconventional myosin-Ib isoform X6

Conserved Domains (3) summary

smart00015
Location:769 → 791

IQ; Calmodulin-binding motif

cd01378
Location:49 → 708

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:903 → 1078

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_047444415.1 → XP_047300371.1 unconventional myosin-Ib isoform X6
XM_047444411.1 → XP_047300367.1 unconventional myosin-Ib isoform X1
XM_005246572.2 → XP_005246629.1 unconventional myosin-Ib isoform X2

See identical proteins and their annotated locations for XP_005246629.1

UniProtKB/Swiss-Prot

O43794, O43795, Q7Z6L5

UniProtKB/TrEMBL

B0I1S9

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_047444413.1 → XP_047300369.1 unconventional myosin-Ib isoform X5
XM_017004158.2 → XP_016859647.1 unconventional myosin-Ib isoform X7

Conserved Domains (3) summary

smart00242
Location:1 → 580

MYSc; Myosin. Large ATPases

cd01378
Location:1 → 567

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:820 → 994

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

191734489..191914303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054342133.1 → XP_054198108.1 unconventional myosin-Ib isoform X1
XM_054342137.1 → XP_054198112.1 unconventional myosin-Ib isoform X4
XM_054342136.1 → XP_054198111.1 unconventional myosin-Ib isoform X3
XM_054342139.1 → XP_054198114.1 unconventional myosin-Ib isoform X6
XM_054342140.1 → XP_054198115.1 unconventional myosin-Ib isoform X6
XM_054342134.1 → XP_054198109.1 unconventional myosin-Ib isoform X1
XM_054342135.1 → XP_054198110.1 unconventional myosin-Ib isoform X2

UniProtKB/Swiss-Prot

O43794, O43795, Q7Z6L5

UniProtKB/TrEMBL

B0I1S9
XM_054342138.1 → XP_054198113.1 unconventional myosin-Ib isoform X5
XM_054342141.1 → XP_054198116.1 unconventional myosin-Ib isoform X7