TSC10B NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: TSC10B
Official Full Name: NAD(P)-binding Rossmann-fold superfamily protein
Primary source: TAIR:AT5G19200
Locus tag: AT5G19200
See related: Araport:AT5G19200
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T24G5.100; T24G5_100
Summary: Encodes one of the Arabidopsis proteins (At3g06060/TSC10A and At5g19200/TSC10B) with significant similarity to the yeast 3-ketodihydrosphinganine (3-KDS) reductase, Tsc10p. Both TSC10A and TSC10B are bona fide 3-KDS reductase as shown by complementation experiment in yeast.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

TSC10B encodes a functionally redundant 3-KDS reductase required for sphingolipid synthesis.
Title: Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana.

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NM_121925.4

Function	Evidence Code	Pubs
enables 3-dehydrosphinganine reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 3-keto-sphinganine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

NP_197421.1

NAD(P)-binding Rossmann-fold superfamily protein; FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage, LP.12 twelve leaves visible; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G06060.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain