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    HPR3 D-isomer specific 2-hydroxyacid dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837811, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HPR3
    Official Full Name
    D-isomer specific 2-hydroxyacid dehydrogenase family protein
    Primary source
    TAIR:AT1G12550
    Locus tag
    AT1G12550
    See related
    Araport:AT1G12550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5O11.29; F5O11_29; hydroxypyruvate reductase 3
    Summary
    Encodes a hydroxypyruvate reductase that reduces HP to glycerate and shows even more activity with glyoxylate, a more upstream intermediate of the photorespiratory cycle. It is likely targeted to the chloroplast where it could provide a compensatory bypass for the reduction of HP and glyoxylate within this compartment.
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    Genomic context

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    See HPR3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (4274531..4276031)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene expansin A7 Neighboring gene Glucose-methanol-choline (GMC) oxidoreductase family protein Neighboring gene phosphoenolpyruvate carboxylase-related kinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hydroxypyruvate-reducing system in Arabidopsis: multiple enzymes for the same end. Timm S, et al. Plant Physiol, 2011 Feb. PMID 21205613, Free PMC Article
    2. Characterization of Arabidopsis thaliana Hydroxyphenylpyruvate Reductases in the Tyrosine Conversion Pathway. Xu JJ, et al. Front Plant Sci, 2018. PMID 30233632, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of AtHPR3 does not impair growth but leads to slightly increased levels of photorespiratory intermediates.
      Title: The hydroxypyruvate-reducing system in Arabidopsis: multiple enzymes for the same end.
    Submit: New GeneRIF Correction

    General gene information

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    NM_101126.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxypyruvate reductase [NAD(P)H] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photorespiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-isomer specific 2-hydroxyacid dehydrogenase family protein
    NP_172716.1
    • D-isomer specific 2-hydroxyacid dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-isomer specific 2-hydroxyacid dehydrogenase family protein (TAIR:AT2G45630.2); Has 29393 Blast hits to 29385 proteins in 2729 species: Archae - 468; Bacteria - 18116; Metazoa - 729; Fungi - 1168; Plants - 597; Viruses - 5; Other Eukaryotes - 8310 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4274531..4276031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101126.3 → NP_172716.1  D-isomer specific 2-hydroxyacid dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LE33
      UniProtKB/TrEMBL
      A0A178WMD4, A0A7G2DSP2
      Conserved Domains (1) summary
      cd12156
      Location:8 → 312
      HPPR; Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LE33.1

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