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    SIP2;1 small and basic intrinsic protein 2;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824862, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIP2;1
    Official Full Name
    small and basic intrinsic protein 2;1
    Primary source
    TAIR:AT3G56950
    Locus tag
    AT3G56950
    See related
    Araport:AT3G56950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SIP2; SMALL AND BASIC INTRINSIC PROTEIN 2; small and basic intrinsic protein 2;1; T8M16.9
    Summary
    One of the Major Intrinsic Proteins(MIPs) which facilitate the passive transport of small molecules across membranes.Belongs to a family of plant aquaporins.Similar to yeast and radish aquaporins. Located on ER.
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    Genomic context

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    See SIP2;1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (21078297..21079925, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DHHC-type zinc finger family protein Neighboring gene ncRNA Neighboring gene dicarboxylate diiron protein, putative (Crd1) Neighboring gene ncRNA Neighboring gene phosphatidyl inositol monophosphate 5 kinase 4 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ER-localized aquaporin SIP2;1 is involved in pollen germination and pollen tube elongation in Arabidopsis thaliana. Sato R, et al. Plant Mol Biol, 2019 Jun. PMID 30963359
    2. Novel type aquaporin SIPs are mainly localized to the ER membrane and show cell-specific expression in Arabidopsis thaliana. Ishikawa F, et al. FEBS Lett, 2005 Oct 24. PMID 16223486
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115554.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    small and basic intrinsic protein 2;1
    NP_001190113.1
    • small and basic intrinsic protein 2;1 (SIP2;1); FUNCTIONS IN: transporter activity; INVOLVED IN: transport; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: Aquaporin-like superfamily protein (TAIR:AT5G18290.2).
    NP_191254.1
    • small and basic intrinsic protein 2;1 (SIP2;1); FUNCTIONS IN: transporter activity; INVOLVED IN: transport; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: Aquaporin-like superfamily protein (TAIR:AT5G18290.2); Has 1253 Blast hits to 1253 proteins in 361 species: Archae - 9; Bacteria - 357; Metazoa - 222; Fungi - 102; Plants - 511; Viruses - 0; Other Eukaryotes - 52 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21078297..21079925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203184.1 → NP_001190113.1  small and basic intrinsic protein 2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J0V0
      Conserved Domains (1) summary
      cl00200
      Location:12 → 218
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    2. NM_115554.4 → NP_191254.1  small and basic intrinsic protein 2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191254.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1K3
      UniProtKB/TrEMBL
      A0A178VEI5, A0A5S9XLL1
      Conserved Domains (1) summary
      cl00200
      Location:12 → 218
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1K3.1

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