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    CER10 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824702, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CER10
    Official Full Name
    3-oxo-5-alpha-steroid 4-dehydrogenase family protein
    Primary source
    TAIR:AT3G55360
    Locus tag
    AT3G55360
    See related
    Araport:AT3G55360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTSC13; ECERIFERUM 10; ECR; ENOYL-COA REDUCTASE; GLASSY HAIR 6; GLH6; TSC13
    Summary
    Enoyl-CoA reductase is involved in all very long chain fatty acids (VLCFA) elongation reactions that are required for cuticular wax, storage lipid and sphingolipid metabolism. The protein is located in the ER, but in contrast to its yeast homolog TSC13 is not particularly enriched in the nuclear envelope-vacuole junction. Mutants in this gene show abnormal organ morphology and stem glossiness. Cells in all tissues are only about 1/3 of the size of wild type cells. The morphological changes are most likely to result from the reduction in the VLCFA content of sphingolipids. Mutants also show abnormalities in the endocytic membrane organization and transport.
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    Genomic context

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    See CER10 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20520930..20523098, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene PsbP-like protein 1 Neighboring gene phragmoplastin interacting protein 1 Neighboring gene PIF / Ping-Pong family of plant transposase Neighboring gene OBF-binding protein 3 Neighboring gene ubiquitin-conjugating enzyme 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis. Zheng H, et al. Plant Cell, 2005 May. PMID 15829606, Free PMC Article
    2. Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system. Gable K, et al. J Exp Bot, 2004 Feb. PMID 14673020
    3. A six-membrane-spanning topology for yeast and Arabidopsis Tsc13p, the enoyl reductases of the microsomal fatty acid elongating system. Paul S, et al. J Biol Chem, 2007 Jun 29. PMID 17463005
    4. Arabidopsis GLASSY HAIR genes promote trichome papillae development. Suo B, et al. J Exp Bot, 2013 Nov. PMID 24014871, Free PMC Article
    5. Chrysotile asbestos and health in Zimbabwe: I. Analysis of miners and millers compensated for asbestos-related diseases since independence (1980). Cullen MR, et al. Am J Ind Med, 1991. PMID 1847001

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115394.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid elongase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables trans-2-enoyl-CoA reductase (NADPH) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables very-long-chain enoyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cutin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome papilla formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of fatty acid elongase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-oxo-5-alpha-steroid 4-dehydrogenase family protein
    NP_191096.1
    • ECERIFERUM 10 (CER10); FUNCTIONS IN: fatty acid elongase activity, trans-2-enoyl-CoA reductase (NADPH) activity, 3-oxo-5-alpha-steroid 4-dehydrogenase activity; INVOLVED IN: sphingolipid metabolic process, wax biosynthetic process; LOCATED IN: endoplasmic reticulum, fatty acid elongase complex, plasma membrane, endoplasmic reticulum membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (InterPro:IPR001104); BEST Arabidopsis thaliana protein match is: 3-oxo-5-alpha-steroid 4-dehydrogenase family protein (TAIR:AT5G16010.1); Has 1087 Blast hits to 1087 proteins in 269 species: Archae - 0; Bacteria - 73; Metazoa - 353; Fungi - 144; Plants - 184; Viruses - 0; Other Eukaryotes - 333 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20520930..20523098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115394.4 → NP_191096.1  3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2U2
      UniProtKB/TrEMBL
      A0A178VGP2, A0A5S9XL07, A0A654FHY9
      Conserved Domains (1) summary
      PLN02560
      Location:1 → 310
      PLN02560; enoyl-CoA reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2U2.1

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