cut7 kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: cut7
Official Full Name: kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7
Primary source: PomBase:SPAC25G10.07c
Locus tag: SPOM_SPAC25G10.07C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See cut7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (4306511..4310337, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.
Title: Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.
The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase.
Title: The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase.
Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe.
Title: Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe.
Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Title: Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
treatment with a microtubule-destabilizing drug not only suppresses cut7 temperature sensitivity but also rescues the lethality resulting from the deletion of cut7, though a single klp2 deletion per se cannot compensate for the loss of Cut7.
Title: Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe.
although deletion of either pkl1 or klp2 rescues temperature-sensitive cut7 mutants, deletion of only pkl1 can bypass the lethality caused by cut7 deletion
Title: Two spatially distinct kinesin-14 proteins, Pkl1 and Klp2, generate collaborative inward forces against kinesin-5 Cut7 in S. pombe.
The study shows that the stepping direction of Cut7, a yeast kinesin-5 motor, depends on the level of motor crowding on the microtubule, and that crowding of Cut7 by non-Cut7 proteins also can drive reversal. Thus, crowding by either dynein microtubule binding domain or Klp2, a kinesin-14, converts Cut7 from net minus end-directed to net plus end-directed stepping.
Title: Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.
Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7, have been reported.
Title: Molecular properties of the N-terminal extension of the fission yeast kinesin-5, Cut7.
In in vitro motility assays, full-length Cut7 moved toward minus-end of microtubules, but the N-terminal half of Cut7 moved toward the opposite direction.
Title: Bidirectional motility of the fission yeast kinesin-5, Cut7.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IC Inferred by Curator more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables minus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in initial mitotic spindle pole body separation	EXP Inferred from Experiment more info	PubMed
involved_in initial mitotic spindle pole body separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule plus-end directed mitotic chromosome migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle elongation (spindle phase three)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle formation (spindle phase one)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IC Inferred by Curator more info
is_active_in microtubule cytoskeleton	HDA more info	PubMed
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in polar microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

4306511..4310337 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019956.3 → NP_594527.1 kinesin-5 family plus-end directed microtubule motor, bimC subfamily Cut7 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_594527.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P24339

Conserved Domains (3) summary

smart00129
Location:72 → 428

KISc; Kinesin motor, catalytic domain. ATPase

COG0419
Location:398 → 966

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01364
Location:70 → 429

KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins