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    itih3b.2 inter-alpha-trypsin inhibitor heavy chain 3b, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100003906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itih3b.2provided by ZNC
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 3b, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050626-133
    See related
    Ensembl:ENSDARG00000100406 AllianceGenome:ZFIN:ZDB-GENE-050626-133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj67a04; zgc:112265; si:ch211-210k13.1
    Summary
    Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See itih3b.2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (37201487..37229222)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (36933926..36962132)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 2 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3b, tandem duplicate 1 Neighboring gene galanin receptor type 1 Neighboring gene interleukin 17 receptor C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification. Jin Q, et al. J Genet Genomics, 2022 Dec. PMID 36460297
    2. Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Gao Y, et al. Cells, 2022 Oct 19. PMID 36291156, Free PMC Article
    3. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article
    4. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100003906

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025164.2 → NP_001020335.2  uncharacterized protein LOC100003906 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CABZ01065568, CABZ01065569, CABZ01065570, CR352285
      UniProtKB/TrEMBL
      A0A8M6Z0Z7
      Related
      ENSDARP00000139541.1, ENSDART00000171273.2

    2. NM_001430905.1 → NP_001417834.1  uncharacterized protein LOC100003906 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CABZ01065568, CABZ01065569, CABZ01065570, CR352285
      UniProtKB/TrEMBL
      A0A8M6Z0Z7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      37201487..37229222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358172.3 → XP_017213661.1  uncharacterized protein LOC100003906 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z0Z7, A0A8M6Z906

    2. XM_017358174.3 → XP_017213663.1  uncharacterized protein LOC100003906 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z8L4, A0A8M6Z908

    3. XM_017358176.3 → XP_017213665.1  uncharacterized protein LOC100003906 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z367, A0A8M6Z908

    4. XM_021479528.2 → XP_021335203.1  uncharacterized protein LOC100003906 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z908, A0A8M9Q6Z2
      Related
      ENSDARP00000142629.1, ENSDART00000173439.2
      Conserved Domains (2) summary
      cl00057
      Location:270 → 446
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl02699
      Location:23 → 147
      VIT; Vault protein inter-alpha-trypsin domain

    5. XM_021479527.2 → XP_021335202.1  uncharacterized protein LOC100003906 isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z0Z7, A0A8M9PUM4
      Conserved Domains (2) summary
      cl00057
      Location:270 → 446
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl02699
      Location:23 → 147
      VIT; Vault protein inter-alpha-trypsin domain

    6. XM_021479529.2 → XP_021335204.1  uncharacterized protein LOC100003906 isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z0Z7, A0A8M9QCW1
      Conserved Domains (2) summary
      cl00057
      Location:270 → 446
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl02699
      Location:23 → 147
      VIT; Vault protein inter-alpha-trypsin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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