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    Ccdc141 coiled-coil domain containing 141 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311134, updated on 9-Dec-2024

    Summary

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    Symbol
    Ccdc141provided by RGD
    Full Name
    coiled-coil domain containing 141provided by RGD
    Primary source
    RGD:1593250
    See related
    EnsemblRapid:ENSRNOG00000012580 AllianceGenome:RGD:1593250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in brain development. Predicted to act upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Predicted to be located in centrosome and cytoplasm. Orthologous to human CCDC141 (coiled-coil domain containing 141). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 630.5), Kidney (RPKM 146.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc141 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (82357046..82517199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61948614..62109968, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63865240..64024208, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486119 Neighboring gene pleckstrin homology domain containing A3 Neighboring gene uncharacterized LOC120101583 Neighboring gene titin Neighboring gene SEC14 and spectrin domain containing 1 Neighboring gene RNA, U6 small nuclear 480 Neighboring gene uncharacterized LOC134486392 Neighboring gene uncharacterized LOC134486391

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. Fukuda T, et al. EMBO Rep, 2016 Dec. PMID 27737934, Free PMC Article
    2. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. Fukuda T, et al. J Biol Chem, 2010 Dec 24. PMID 20956536, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 141
    Names
    coiled-coil protein associated with myosin II and DISC1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430394.1 → NP_001417323.1  coiled-coil domain-containing protein 141

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3ZEY0
      UniProtKB/TrEMBL
      A6HMI7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      82357046..82517199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749494.6 → XP_003749542.2  coiled-coil domain-containing protein 141 isoform X1

      UniProtKB/Swiss-Prot
      D3ZEY0
      UniProtKB/TrEMBL
      A6HMI7
      Conserved Domains (5) summary
      COG0419
      Location:219 → 804
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00176
      Location:132 → 356
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:1409 → 1498
      I-set; Immunoglobulin I-set domain
      cl02488
      Location:260 → 458
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl11960
      Location:1425 → 1499
      Ig; Immunoglobulin domain

    2. XM_063285277.1 → XP_063141347.1  coiled-coil domain-containing protein 141 isoform X1

      Related
      ENSRNOP00000103878.1, ENSRNOT00000149776.1

    3. XM_063285279.1 → XP_063141349.1  coiled-coil domain-containing protein 141 isoform X2

      UniProtKB/TrEMBL
      A6HMI8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZEY0.2 GenPept UniProtKB/Swiss-Prot:D3ZEY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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