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    Eloc elongin C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64525, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Elocprovided by RGD
    Official Full Name
    elongin Cprovided by RGD
    Primary source
    RGD:620658
    See related
    EnsemblRapid:ENSRNOG00000076409 AllianceGenome:RGD:620658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tceb1
    Summary
    Predicted to enable protein-macromolecule adaptor activity and transcription corepressor binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of transcription elongation by RNA polymerase II. Part of VCB complex. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 150.1), Brain (RPKM 125.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eloc in Genome Data Viewer
    Location:
    5q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (7444769..7461187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (2661527..2677893)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2042991..2059357)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 70 Neighboring gene isopentenyl-diphosphate delta isomerase 1, pseudogene 1 Neighboring gene uncharacterized LOC134486910 Neighboring gene ubiquitin-conjugating enzyme E2W Neighboring gene spindlin-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII. Garrett KP, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202474, Free PMC Article
    2. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. Takagi Y, et al. J Biol Chem, 1997 Oct 24. PMID 9341197
    3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. Bradsher JN, et al. J Biol Chem, 1993 Dec 5. PMID 8244996
    4. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower CS, et al. J Biol Chem, 1999 May 7. PMID 10224134
    5. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL. Physiology (Bethesda), 2009 Apr. PMID 19364912

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72822

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in target-directed miRNA degradation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of VCB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongin-C
    Names
    RNA polymerase II transcription factor SIII subunit C
    SIII p15
    elongation factor SIII p15 subunit
    elongin 15 kDa subunit
    stromal membrane-associated protein SMAP1B homolog
    transcription elongation factor B (SIII), polypeptide 1
    transcription elongation factor B polypeptide 1
    transcription elongation factor B subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270561.2 → NP_001257490.1  elongin-C

      See identical proteins and their annotated locations for NP_001257490.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A0A096MIY6, A6JFA3
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    2. NM_001270562.2 → NP_001257491.1  elongin-C

      See identical proteins and their annotated locations for NP_001257491.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A0A096MIY6, A6JFA3
      Related
      ENSRNOP00000101569.1, ENSRNOT00000140131.1
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    3. NM_001270563.2 → NP_001257492.1  elongin-C

      See identical proteins and their annotated locations for NP_001257492.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A0A096MIY6, A6JFA3
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    4. NM_001430040.1 → NP_001416969.1  elongin-C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A6JFA3

    5. NM_001430041.1 → NP_001416970.1  elongin-C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A6JFA3

    6. NM_001430042.1 → NP_001416971.1  elongin-C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A6JFA3

    7. NM_022593.5 → NP_072115.1  elongin-C

      See identical proteins and their annotated locations for NP_072115.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A0A096MIY6, A6JFA3
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      7444769..7461187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237724.5 → XP_006237786.1  elongin-C isoform X1

      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    2. XM_039110711.2 → XP_038966639.1  elongin-C isoform X1

      UniProtKB/Swiss-Prot
      P83941
      UniProtKB/TrEMBL
      A0A096MIY6, A6JFA3
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83941.1 GenPept UniProtKB/Swiss-Prot:P83941

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