Ina internexin neuronal intermediate filament protein, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inaprovided by MGI
Official Full Name: internexin neuronal intermediate filament protein, alphaprovided by MGI
Primary source: MGI:MGI:96568
See related: Ensembl:ENSMUSG00000034336 AllianceGenome:MGI:96568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NF66; NF-66; alpha-Inx
Summary: A structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within cellular response to leukemia inhibitory factor and neurofilament cytoskeleton organization. Located in neurofilament. Is active in Schaffer collateral - CA1 synapse and postsynapse. Is expressed in several structures, including gut; nervous system; neural ectoderm; and sensory organ. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 162.9), CNS E14 (RPKM 140.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 39.07 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47003120..47013766)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47014681..47025327)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurofilament light chain (NFL) and neuronal intermediate filament protein alpha-internexin accumulate in axon swellings in the spinal white matter in superoxide dismutase (SOD)-1 mouse.
Title: Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity.
RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and NF-M genes
Title: RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes.
abnormal accumulation of neuronal IFs in the swelling axons and abnormal translocation of alpha-internexin in the nuclei of the spinal motor neurons from dystonia musculorum mice may not directly cause cell death of the spinal motor neurons
Title: Abnormal cellular translocation of alpha-internexin in spinal motor neurons of Dystonia musculorum mice.
Therefore, the cre transgene driven by mouse alpha-internexin promoter, described here, provides a useful animal model to specifically manipulate genes in the developing nervous system.
Title: Neural expression of alpha-internexin promoter in vitro and in vivo.
Alpha-internexin coassembles with all 3 neurofilament proteins into a single network of filaments. All of them are functionally interdependent. It is a fourth subunit of neurofilaments in the adult CNS.
Title: Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L27220 (e-PCR)
- UniSTS:160854

NoName (e-PCR)
- UniSTS:225207

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic intermediate filament cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within intermediate filament cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurofilament cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postsynaptic intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	HDA more info	PubMed
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic intermediate filament cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-internexin

Names: 66 kDa neurofilament protein; neurofilament-66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.