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    GEN1 GEN1 Holliday junction 5' flap endonuclease [ Pan troglodytes (chimpanzee) ]

    Gene ID: 470313, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GEN1provided by VGNC
    Official Full Name
    GEN1 Holliday junction 5' flap endonucleaseprovided by VGNC
    Primary source
    VGNC:VGNC:271
    Locus tag
    CK820_G0009712
    See related
    Ensembl:ENSPTRG00000011678
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See GEN1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 12 NC_072410.2 (105089081..105119754, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2A NC_072399.1 (17733486..17764771)

    Chromosome 12 - NC_072410.2Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily S member 3 Neighboring gene mesogenin 1 Neighboring gene structural maintenance of chromosomes 6 Neighboring gene visinin like 1 Neighboring gene RAD51 associated protein 2 Neighboring gene 26S proteasome regulatory subunit 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables four-way junction DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flap endonuclease GEN homolog 1
    Names
    Gen endonuclease homolog 1
    Gen homolog 1, endonuclease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      105089081..105119754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063790105.1 → XP_063646175.1  flap endonuclease GEN homolog 1 isoform X2

    2. XM_003949761.6 → XP_003949810.1  flap endonuclease GEN homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_003949810.1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9
      Conserved Domains (2) summary
      cd09905
      Location:195 → 338
      H3TH_GEN1; H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09869
      Location:1 → 193
      PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    3. XM_009442041.5 → XP_009440316.1  flap endonuclease GEN homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_009440316.1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9
      Related
      ENSPTRP00000020072.4
      Conserved Domains (2) summary
      cd09905
      Location:195 → 338
      H3TH_GEN1; H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09869
      Location:1 → 193
      PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    4. XM_063790102.1 → XP_063646172.1  flap endonuclease GEN homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9

    5. XM_024354217.3 → XP_024209985.1  flap endonuclease GEN homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9
      Conserved Domains (2) summary
      cd09905
      Location:195 → 338
      H3TH_GEN1; H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09869
      Location:1 → 193
      PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    6. XM_063790107.1 → XP_063646177.1  flap endonuclease GEN homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9

    7. XM_063790106.1 → XP_063646176.1  flap endonuclease GEN homolog 1 isoform X2

    8. XM_009442040.5 → XP_009440315.1  flap endonuclease GEN homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_009440315.1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9
      Related
      ENSPTRP00000081984.1
      Conserved Domains (2) summary
      cd09905
      Location:195 → 338
      H3TH_GEN1; H3TH domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09869
      Location:1 → 193
      PIN_GEN1; PIN domain of Gap Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    9. XM_063790101.1 → XP_063646171.1  flap endonuclease GEN homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A2J8NLN5, A0A6D2XEQ3, H2QHG9

    10. XM_063790104.1 → XP_063646174.1  flap endonuclease GEN homolog 1 isoform X2

    11. XM_063790103.1 → XP_063646173.1  flap endonuclease GEN homolog 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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