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    Clip1 CAP-GLY domain containing linker protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56430, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Clip1provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 1provided by MGI
    Primary source
    MGI:MGI:1928401
    See related
    Ensembl:ENSMUSG00000049550 AllianceGenome:MGI:1928401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsn; CYLN1; Clip50; restin; CLIP170; CLIP-170; mKIAA4046; 1110007I12Rik; 4631429H07Rik
    Summary
    Enables microtubule plus-end binding activity. Acts upstream of or within protein transport into plasma membrane raft. Located in microtubule plus-end and nuclear envelope. Is expressed in several structures, including brain; early conceptus; heart; and spleen. Orthologous to human CLIP1 (CAP-Gly domain containing linker protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clip1 in Genome Data Viewer
    Location:
    5 F; 5 63.06 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123715857..123822527, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123577794..123684606, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2175 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene microRNA 7647 Neighboring gene STARR-positive B cell enhancer mm9_chr5:123993667-123993967 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E2176 Neighboring gene STARR-seq mESC enhancer starr_14324 Neighboring gene predicted gene, 24840 Neighboring gene STARR-seq mESC enhancer starr_14325 Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_14326 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CLIP-50 immunolocalization during mouse spermiogenesis suggests a role in shaping the sperm nucleus. Tarsounas M, et al. Dev Biol, 2001 Aug 15. PMID 11476580
    2. [Restin expressed in vivo suppresses the growth of tumors in nude mice]. Xu R, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Sep. PMID 12198558
    3. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. Lansbergen G, et al. J Cell Biol, 2004 Sep 27. PMID 15381688, Free PMC Article
    4. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Akhmanova A, et al. Genes Dev, 2005 Oct 15. PMID 16230537, Free PMC Article
    5. Phosphorylation controls autoinhibition of cytoplasmic linker protein-170. Lee HS, et al. Mol Biol Cell, 2010 Aug 1. PMID 20519438, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-beta pathway.
      Title: CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-β pathway.
    2. Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency.
      Title: Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency.
    3. AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
      Title: AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
    4. Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
      Title: Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
    5. we report an unexpected finding that CLIP170 negatively regulates TLR4 signaling by the targeted ubiquitination and degradation of TIRAP. Furthermore, we observed that CLIP170 expression is modulated by LPS to maintain the cellular homeostasis.
      Title: Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP.
    6. Drosophila CLIP-190 (and potentially also mouse CLIP-170) does not possess a significant role in the axon growth-promoting microtubule machinery.
      Title: Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.
    7. Cytoplasmic linker protein 170 was ubiquitously expressed in mouse kidney, liver, lung, normal non-atherosclerotic aorta, and atherosclerotic aorta and was partly localized in the vascular endothelium.
      Title: Identification of a cytoplasmic linker protein as a potential target for neovascularization.
    8. Phosphorylation regulates CLIP-170 conformational changes resulting in its autoinhibition.
      Title: Phosphorylation controls autoinhibition of cytoplasmic linker protein-170.
    9. Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends.
      Title: Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends.
    10. CLIP170 is a key regulator of microtubule stabilization that is required for enhanced cell spreading and phagocytosis in activated macrophages.
      Title: Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4046

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein transport into plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with macropinosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 1
    Names
    Clip 170
    Reed-Steinberg cell-espressed intermediate filament-associated protein
    cytoplasmic linker protein 170
    cytoplasmic linker protein 50
    restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291229.2 → NP_001278158.1  CAP-Gly domain-containing linker protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS71663.1
      UniProtKB/Swiss-Prot
      Q922J3
      Related
      ENSMUSP00000107190.2, ENSMUST00000111564.8
      Conserved Domains (3) summary
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam15964
      Location:413 → 1070
      CCCAP; Centrosomal colon cancer autoantigen protein family
      pfam16641
      Location:1293 → 1309
      CLIP1_ZNF; CLIP1 zinc knuckle

    2. NM_001347468.2 → NP_001334397.1  CAP-Gly domain-containing linker protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS84958.1
      UniProtKB/TrEMBL
      D3Z3M7, F6RCU2
      Related
      ENSMUSP00000068241.6, ENSMUST00000063905.12

    3. NM_001359220.2 → NP_001346149.1  CAP-Gly domain-containing linker protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (3) summary
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1367 → 1383
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:404 → 1298
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001359221.2 → NP_001346150.1  CAP-Gly domain-containing linker protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      F6RCU2
      Related
      ENSMUSP00000121425.2, ENSMUST00000137363.8
      Conserved Domains (3) summary
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1291 → 1307
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:404 → 1222
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001359222.2 → NP_001346151.1  CAP-Gly domain-containing linker protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      F6RCU2
      Conserved Domains (3) summary
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1256 → 1272
      CLIP1_ZNF; CLIP1 zinc knuckle
      cl25732
      Location:404 → 1187
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001359223.2 → NP_001346152.1  CAP-Gly domain-containing linker protein 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (2) summary
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:351 → 1093
      SMC_N; RecF/RecN/SMC N terminal domain

    7. NM_001359224.2 → NP_001346153.1  CAP-Gly domain-containing linker protein 1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Conserved Domains (2) summary
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:369 → 1134
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001428314.1 → NP_001415243.1  CAP-Gly domain-containing linker protein 1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      F8WIA1

    9. NM_001428315.1 → NP_001415244.1  CAP-Gly domain-containing linker protein 1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      F8WIA1

    10. NM_001428316.1 → NP_001415245.1  CAP-Gly domain-containing linker protein 1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      F8WIA1

    11. NM_001428317.1 → NP_001415246.1  CAP-Gly domain-containing linker protein 1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC129569
      UniProtKB/TrEMBL
      D3Z2Z1

    12. NM_001428318.1 → NP_001415247.1  CAP-Gly domain-containing linker protein 1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC129569

    13. NM_001428319.1 → NP_001415248.1  CAP-Gly domain-containing linker protein 1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC129569

    14. NM_001428320.1 → NP_001415249.1  CAP-Gly domain-containing linker protein 1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC129569

    15. NM_001428321.1 → NP_001415250.1  CAP-Gly domain-containing linker protein 1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC129569

    16. NM_001428322.1 → NP_001415251.1  CAP-Gly domain-containing linker protein 1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC129569

    17. NM_001428323.1 → NP_001415252.1  CAP-Gly domain-containing linker protein 1 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC129569

    18. NM_001428324.1 → NP_001415253.1  CAP-Gly domain-containing linker protein 1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC129569

    19. NM_001428325.1 → NP_001415254.1  CAP-Gly domain-containing linker protein 1 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC129569

    20. NM_001428326.1 → NP_001415255.1  CAP-Gly domain-containing linker protein 1 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC129569

    21. NM_001428327.1 → NP_001415256.1  CAP-Gly domain-containing linker protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC129569

    22. NM_001428328.1 → NP_001415257.1  CAP-Gly domain-containing linker protein 1 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC129569

    23. NM_001428329.1 → NP_001415258.1  CAP-Gly domain-containing linker protein 1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC129569

    24. NM_019765.6 → NP_062739.2  CAP-Gly domain-containing linker protein 1 isoform a

      See identical proteins and their annotated locations for NP_062739.2

      Status: VALIDATED

      Source sequence(s)
      AC129569
      Consensus CDS
      CCDS19667.1
      UniProtKB/Swiss-Prot
      Q571L7, Q922J3
      Related
      ENSMUSP00000107192.3, ENSMUST00000111566.9
      Conserved Domains (3) summary
      pfam05483
      Location:344 → 1112
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam01302
      Location:214 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1369 → 1385
      CLIP1_ZNF; CLIP1 zinc knuckle

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123715857..123822527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254713.2 → XP_030110573.1  CAP-Gly domain-containing linker protein 1 isoform X10

      Conserved Domains (4) summary
      COG1196
      Location:649 → 1473
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:338 → 857
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2103 → 2119
      CLIP1_ZNF; CLIP1 zinc knuckle

    2. XM_006530416.5 → XP_006530479.1  CAP-Gly domain-containing linker protein 1 isoform X8

      Conserved Domains (4) summary
      COG1196
      Location:660 → 1484
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:338 → 927
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2114 → 2130
      CLIP1_ZNF; CLIP1 zinc knuckle

    3. XM_036165355.1 → XP_036021248.1  CAP-Gly domain-containing linker protein 1 isoform X38

      Conserved Domains (3) summary
      COG1196
      Location:404 → 1187
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1254 → 1270
      CLIP1_ZNF; CLIP1 zinc knuckle

    4. XM_017321029.3 → XP_017176518.1  CAP-Gly domain-containing linker protein 1 isoform X37

      Conserved Domains (3) summary
      COG1196
      Location:369 → 1194
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1263 → 1279
      CLIP1_ZNF; CLIP1 zinc knuckle

    5. XM_036165352.1 → XP_036021245.1  CAP-Gly domain-containing linker protein 1 isoform X34

      Conserved Domains (3) summary
      COG1196
      Location:420 → 1226
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1295 → 1311
      CLIP1_ZNF; CLIP1 zinc knuckle

    6. XM_006530423.5 → XP_006530486.1  CAP-Gly domain-containing linker protein 1 isoform X32

      Conserved Domains (3) summary
      COG1196
      Location:420 → 1233
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1302 → 1318
      CLIP1_ZNF; CLIP1 zinc knuckle

    7. XM_006530419.5 → XP_006530482.1  CAP-Gly domain-containing linker protein 1 isoform X12

      Conserved Domains (5) summary
      COG1196
      Location:420 → 1223
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:1640 → 2016
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:900 → 1797
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2058 → 2074
      CLIP1_ZNF; CLIP1 zinc knuckle

    8. XM_030254716.2 → XP_030110576.1  CAP-Gly domain-containing linker protein 1 isoform X23

      Conserved Domains (3) summary
      COG1196
      Location:420 → 1309
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1378 → 1394
      CLIP1_ZNF; CLIP1 zinc knuckle

    9. XM_006530415.5 → XP_006530478.1  CAP-Gly domain-containing linker protein 1 isoform X7

      Conserved Domains (4) summary
      COG1196
      Location:680 → 1504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:352 → 947
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2134 → 2150
      CLIP1_ZNF; CLIP1 zinc knuckle

    10. XM_036165353.1 → XP_036021246.1  CAP-Gly domain-containing linker protein 1 isoform X35

      UniProtKB/TrEMBL
      F6RCU2
      Conserved Domains (3) summary
      COG1196
      Location:404 → 1222
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1289 → 1305
      CLIP1_ZNF; CLIP1 zinc knuckle

    11. XM_017321020.3 → XP_017176509.1  CAP-Gly domain-containing linker protein 1 isoform X13

      Conserved Domains (5) summary
      COG1196
      Location:351 → 1078
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:1636 → 2012
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:896 → 1793
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2054 → 2070
      CLIP1_ZNF; CLIP1 zinc knuckle

    12. XM_036165346.1 → XP_036021239.1  CAP-Gly domain-containing linker protein 1 isoform X27

      Conserved Domains (3) summary
      COG1196
      Location:351 → 1076
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1328 → 1344
      CLIP1_ZNF; CLIP1 zinc knuckle

    13. XM_036165344.1 → XP_036021237.1  CAP-Gly domain-containing linker protein 1 isoform X26

      Conserved Domains (4) summary
      COG1196
      Location:462 → 1261
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 525
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1330 → 1346
      CLIP1_ZNF; CLIP1 zinc knuckle

    14. XM_006530422.5 → XP_006530485.1  CAP-Gly domain-containing linker protein 1 isoform X20

      Related
      ENSMUSP00000107186.2, ENSMUST00000111561.8
      Conserved Domains (3) summary
      COG1196
      Location:351 → 1152
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1404 → 1420
      CLIP1_ZNF; CLIP1 zinc knuckle

    15. XM_036165337.1 → XP_036021230.1  CAP-Gly domain-containing linker protein 1 isoform X19

      Conserved Domains (4) summary
      COG1196
      Location:462 → 1337
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 525
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1406 → 1422
      CLIP1_ZNF; CLIP1 zinc knuckle

    16. XM_036165336.1 → XP_036021229.1  CAP-Gly domain-containing linker protein 1 isoform X18

      Conserved Domains (4) summary
      COG1196
      Location:351 → 1152
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1413 → 1429
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:1058 → 1338
      pneumo_PspA; pneumococcal surface protein A

    17. XM_006530412.5 → XP_006530475.1  CAP-Gly domain-containing linker protein 1 isoform X5

      Conserved Domains (4) summary
      COG1196
      Location:715 → 1539
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351 → 982
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2169 → 2185
      CLIP1_ZNF; CLIP1 zinc knuckle

    18. XM_036165354.1 → XP_036021247.1  CAP-Gly domain-containing linker protein 1 isoform X36

      Conserved Domains (3) summary
      COG1196
      Location:404 → 1198
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1265 → 1281
      CLIP1_ZNF; CLIP1 zinc knuckle

    19. XM_036165348.1 → XP_036021241.1  CAP-Gly domain-containing linker protein 1 isoform X30

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1237
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1304 → 1320
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:336 → 603
      pneumo_PspA; pneumococcal surface protein A

    20. XM_036165347.1 → XP_036021240.1  CAP-Gly domain-containing linker protein 1 isoform X29

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1237
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1306 → 1322
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:336 → 603
      pneumo_PspA; pneumococcal surface protein A

    21. XM_036165339.1 → XP_036021232.1  CAP-Gly domain-containing linker protein 1 isoform X22

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1313
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1380 → 1396
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:349 → 603
      pneumo_PspA; pneumococcal surface protein A

    22. XM_036165338.1 → XP_036021231.1  CAP-Gly domain-containing linker protein 1 isoform X21

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1313
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1382 → 1398
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:349 → 603
      pneumo_PspA; pneumococcal surface protein A

    23. XM_006530413.5 → XP_006530476.1  CAP-Gly domain-containing linker protein 1 isoform X6

      Conserved Domains (4) summary
      COG1196
      Location:691 → 1515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:352 → 958
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2145 → 2161
      CLIP1_ZNF; CLIP1 zinc knuckle

    24. XM_036165351.1 → XP_036021244.1  CAP-Gly domain-containing linker protein 1 isoform X33

      UniProtKB/TrEMBL
      F6RCU2
      Conserved Domains (3) summary
      COG1196
      Location:420 → 1233
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1300 → 1316
      CLIP1_ZNF; CLIP1 zinc knuckle

    25. XM_036165350.1 → XP_036021243.1  CAP-Gly domain-containing linker protein 1 isoform X31

      UniProtKB/TrEMBL
      F6RCU2
      Conserved Domains (3) summary
      COG1196
      Location:420 → 1233
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1302 → 1318
      CLIP1_ZNF; CLIP1 zinc knuckle

    26. XM_017321026.3 → XP_017176515.1  CAP-Gly domain-containing linker protein 1 isoform X28

      UniProtKB/TrEMBL
      F6RCU2
      Conserved Domains (3) summary
      COG1196
      Location:404 → 1240
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1309 → 1325
      CLIP1_ZNF; CLIP1 zinc knuckle

    27. XM_006530418.5 → XP_006530481.1  CAP-Gly domain-containing linker protein 1 isoform X11

      Conserved Domains (5) summary
      COG1196
      Location:351 → 1089
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:1647 → 2023
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:907 → 1804
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2065 → 2081
      CLIP1_ZNF; CLIP1 zinc knuckle

    28. XM_036165342.1 → XP_036021235.1  CAP-Gly domain-containing linker protein 1 isoform X25

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1272
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1339 → 1355
      CLIP1_ZNF; CLIP1 zinc knuckle

    29. XM_036165341.1 → XP_036021234.1  CAP-Gly domain-containing linker protein 1 isoform X24

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1272
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1341 → 1357
      CLIP1_ZNF; CLIP1 zinc knuckle

    30. XM_006530417.5 → XP_006530480.1  CAP-Gly domain-containing linker protein 1 isoform X9

      Conserved Domains (6) summary
      COG1196
      Location:473 → 1269
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:1686 → 2062
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:946 → 1843
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2104 → 2120
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17380
      Location:343 → 533
      DUF5401; Family of unknown function (DUF5401)

    31. XM_006530421.5 → XP_006530484.1  CAP-Gly domain-containing linker protein 1 isoform X17

      Related
      ENSMUSP00000031382.8, ENSMUST00000031382.14
      Conserved Domains (4) summary
      COG1196
      Location:473 → 1348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1415 → 1431
      CLIP1_ZNF; CLIP1 zinc knuckle

    32. XM_017321022.3 → XP_017176511.1  CAP-Gly domain-containing linker protein 1 isoform X16

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1417 → 1433
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17380
      Location:343 → 533
      DUF5401; Family of unknown function (DUF5401)

    33. XM_036165334.1 → XP_036021227.1  CAP-Gly domain-containing linker protein 1 isoform X15

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1355
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1422 → 1438
      CLIP1_ZNF; CLIP1 zinc knuckle

    34. XM_006530420.5 → XP_006530483.1  CAP-Gly domain-containing linker protein 1 isoform X14

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1355
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1424 → 1440
      CLIP1_ZNF; CLIP1 zinc knuckle
      pfam17380
      Location:343 → 533
      DUF5401; Family of unknown function (DUF5401)

    35. XM_006530411.5 → XP_006530474.1  CAP-Gly domain-containing linker protein 1 isoform X4

      Conserved Domains (4) summary
      COG1196
      Location:726 → 1550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1141 → 2095
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2171 → 2187
      CLIP1_ZNF; CLIP1 zinc knuckle

    36. XM_006530410.5 → XP_006530473.1  CAP-Gly domain-containing linker protein 1 isoform X3

      Conserved Domains (5) summary
      COG1196
      Location:726 → 1550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351 → 993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam09787
      Location:1911 → 2129
      Golgin_A5; Golgin subfamily A member 5
      pfam16641
      Location:2173 → 2189
      CLIP1_ZNF; CLIP1 zinc knuckle

    37. XM_006530409.5 → XP_006530472.1  CAP-Gly domain-containing linker protein 1 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:726 → 1550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351 → 993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2178 → 2194
      CLIP1_ZNF; CLIP1 zinc knuckle

    38. XM_006530407.5 → XP_006530470.1  CAP-Gly domain-containing linker protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006530470.1

      Conserved Domains (4) summary
      COG1196
      Location:726 → 1550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351 → 993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2180 → 2196
      CLIP1_ZNF; CLIP1 zinc knuckle

    39. XM_030254714.1 → XP_030110574.1  CAP-Gly domain-containing linker protein 1 isoform X12

      Conserved Domains (5) summary
      COG1196
      Location:420 → 1223
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:1640 → 2016
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:900 → 1797
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2058 → 2074
      CLIP1_ZNF; CLIP1 zinc knuckle

    40. XM_030254712.1 → XP_030110572.1  CAP-Gly domain-containing linker protein 1 isoform X7

      Conserved Domains (4) summary
      COG1196
      Location:680 → 1504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:352 → 947
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2134 → 2150
      CLIP1_ZNF; CLIP1 zinc knuckle

    41. XM_011248233.3 → XP_011246535.1  CAP-Gly domain-containing linker protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011246535.1

      Conserved Domains (4) summary
      COG1196
      Location:726 → 1550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:351 → 993
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:2180 → 2196
      CLIP1_ZNF; CLIP1 zinc knuckle

    42. XM_036165349.1 → XP_036021242.1  CAP-Gly domain-containing linker protein 1 isoform X30

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1237
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1304 → 1320
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:336 → 603
      pneumo_PspA; pneumococcal surface protein A

    43. XM_036165343.1 → XP_036021236.1  CAP-Gly domain-containing linker protein 1 isoform X25

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1272
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1339 → 1355
      CLIP1_ZNF; CLIP1 zinc knuckle

    44. XM_036165335.1 → XP_036021228.1  CAP-Gly domain-containing linker protein 1 isoform X17

      Conserved Domains (4) summary
      COG1196
      Location:473 → 1348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17380
      Location:356 → 536
      DUF5401; Family of unknown function (DUF5401)
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1415 → 1431
      CLIP1_ZNF; CLIP1 zinc knuckle

    45. XM_036165340.1 → XP_036021233.1  CAP-Gly domain-containing linker protein 1 isoform X22

      Conserved Domains (4) summary
      COG1196
      Location:477 → 1313
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:213 → 277
      CAP_GLY; CAP-Gly domain
      pfam16641
      Location:1380 → 1396
      CLIP1_ZNF; CLIP1 zinc knuckle
      NF033930
      Location:349 → 603
      pneumo_PspA; pneumococcal surface protein A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922J3.1 GenPept UniProtKB/Swiss-Prot:Q922J3

    Gene LinkOut

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