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    Xpnpep2 X-prolyl aminopeptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xpnpep2provided by RGD
    Official Full Name
    X-prolyl aminopeptidase 2provided by RGD
    Primary source
    RGD:621277
    See related
    EnsemblRapid:ENSRNOG00000004009 AllianceGenome:RGD:621277
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mAPP
    Summary
    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 505.2), Liver (RPKM 225.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Xpnpep2 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132165696..132194937)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127287765..127317036)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (134940656..134969874)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene OCRL, inositol polyphosphate-5-phosphatase Neighboring gene uncharacterized LOC134484146 Neighboring gene apelin Neighboring gene SAM and SH3 domain containing 3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats. Banu SK, et al. Biol Reprod, 2015 Mar. PMID 25568306, Free PMC Article
    2. Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors. Liu G, et al. Pediatr Res, 2007 Jul. PMID 17515839
    3. Rat and mouse membrane aminopeptidase P: structure analysis and tissue distribution. Erşahin C, et al. Arch Biochem Biophys, 2003 Sep 15. PMID 12941294
    4. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Prueitt RL, et al. Cytogenet Cell Genet, 2000. PMID 10894934
    5. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, et al. J Pharmacol Sci, 2005 Sep. PMID 16177542

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xpnpep2 could be a target for heavy metals that impact follicle development by altering the ration of collagens.
      Title: Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats.
    2. Results describe the organ distribution, developmental change and specific inhibitors of prolidases I and II in the rat.
      Title: Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 2
    Names
    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    membrane-bound APP
    membrane-bound aminopeptidase P
    xaa-Pro aminopeptidase 2-like
    NP_476496.1
    XP_008771735.1
    XP_008771736.1
    XP_017457387.1
    XP_038955355.1
    XP_038955356.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057155.4 → NP_476496.1  xaa-Pro aminopeptidase 2 precursor

      See identical proteins and their annotated locations for NP_476496.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q99MA2
      UniProtKB/TrEMBL
      A0A8I5ZM13
      Related
      ENSRNOP00000079032.1, ENSRNOT00000102614.2
      Conserved Domains (4) summary
      cd01085
      Location:365 → 583
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:53 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:584 → 648
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132165696..132194937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601898.3 → XP_017457387.1  xaa-Pro aminopeptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZM13, A0A8L2UHP8
      Related
      ENSRNOP00000005604.4, ENSRNOT00000005604.7

    2. XM_008773513.4 → XP_008771735.1  xaa-Pro aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_008771735.1

      UniProtKB/Swiss-Prot
      Q99MA2
      UniProtKB/TrEMBL
      A0A8I5ZM13
      Related
      ENSRNOP00000095320.1, ENSRNOT00000098779.2
      Conserved Domains (4) summary
      cd01085
      Location:365 → 583
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:53 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:584 → 648
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    3. XM_008773514.4 → XP_008771736.1  xaa-Pro aminopeptidase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM13
      Conserved Domains (4) summary
      cd01085
      Location:314 → 532
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:3 → 126
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:533 → 597
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:144 → 310
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    4. XM_039099427.2 → XP_038955355.1  xaa-Pro aminopeptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZM13
      Conserved Domains (4) summary
      cd01085
      Location:365 → 577
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:54 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:578 → 642
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    5. XM_039099428.2 → XP_038955356.1  xaa-Pro aminopeptidase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM13
      Conserved Domains (4) summary
      cd01085
      Location:314 → 532
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:3 → 126
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:533 → 597
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:144 → 310
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MA2.1 GenPept UniProtKB/Swiss-Prot:Q99MA2

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