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    Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hecw2provided by RGD
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1593244
    See related
    EnsemblRapid:ENSRNOG00000013257 AllianceGenome:RGD:1593244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis; regulation of mitotic metaphase/anaphase transition; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitotic spindle. Predicted to be active in cytoplasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 86.0), Lung (RPKM 72.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hecw2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (62853904..63247472, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (55359462..55753106, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60451476..60843160, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 7 Neighboring gene uncharacterized LOC120094686 Neighboring gene serine/threonine kinase 17b Neighboring gene uncharacterized LOC134480576 Neighboring gene coiled-coil domain containing 150 Neighboring gene ribosomal protein L31 like 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW2
    NP_001101688.1
    XP_006244974.1
    XP_017451936.1
    XP_038939526.1
    XP_038939527.1
    XP_038939528.1
    XP_038939529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108218.1 → NP_001101688.1  E3 ubiquitin-protein ligase HECW2

      See identical proteins and their annotated locations for NP_001101688.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6INZ4, D4ADD3
      Related
      ENSRNOP00000017761.5, ENSRNOT00000017761.7
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:993 → 1024
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:396 → 741
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1222 → 1576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:921 → 987
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      62853904..63247472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083599.2 → XP_038939527.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A6INZ4, D4ADD3
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:993 → 1024
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:396 → 741
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1222 → 1576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:921 → 987
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    2. XM_017596447.3 → XP_017451936.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A6INZ4, D4ADD3
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:993 → 1024
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:396 → 741
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1222 → 1576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:921 → 987
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    3. XM_039083600.2 → XP_038939528.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A6INZ4, D4ADD3
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:993 → 1024
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:396 → 741
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1222 → 1576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:921 → 987
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    4. XM_039083598.2 → XP_038939526.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A6INZ4, D4ADD3
      Conserved Domains (8) summary
      pfam06390
      Location:464 → 632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:993 → 1024
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:396 → 741
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1222 → 1576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815 → 844
      WW; WW domain
      pfam16562
      Location:45 → 162
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:921 → 987
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    5. XM_006244912.5 → XP_006244974.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      Conserved Domains (8) summary
      pfam06390
      Location:333 → 501
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:54 → 190
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:862 → 893
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:265 → 610
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1091 → 1445
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:684 → 713
      WW; WW domain
      pfam16562
      Location:1 → 31
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:790 → 856
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1

    6. XM_039083601.2 → XP_038939529.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      Conserved Domains (8) summary
      pfam06390
      Location:333 → 501
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:54 → 190
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:862 → 893
      WW; Domain with 2 conserved Trp (W) residues
      COG5271
      Location:265 → 610
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00078
      Location:1091 → 1445
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:684 → 713
      WW; WW domain
      pfam16562
      Location:1 → 31
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam18436
      Location:790 → 856
      HECW1_helix; Helical box domain of E3 ubiquitin-protein ligase HECW1
    Nucleotide Protein Strain
    Heading Accession and Version

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