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    Dock10 dedicator of cytokinesis 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dock10provided by RGD
    Official Full Name
    dedicator of cytokinesis 10provided by RGD
    Primary source
    RGD:1561963
    See related
    EnsemblRapid:ENSRNOG00000053200 AllianceGenome:RGD:1561963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561963
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and regulation of postsynapse assembly. Predicted to be located in cytosol; dendritic spine; and nucleoplasm. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 272.4), Thymus (RPKM 170.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock10 in Genome Data Viewer
    Location:
    9q34
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (89291936..89549871, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (81843599..82101540, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (86424638..86571854, complement) , (86312470..86423054, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-18-like Neighboring gene coiled-coil domain containing 195 Neighboring gene ring finger protein 11-like 2 Neighboring gene high mobility group protein B1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. Yelo E, et al. Mol Immunol, 2008 Jul. PMID 18499258
    2. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Gadea G, et al. Curr Biol, 2008 Oct 14. PMID 18835169
    3. Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue. García-Serna AM, et al. Immunobiology, 2016 Dec. PMID 27502165
    4. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Matsuda T, et al. Immun Ageing, 2015. PMID 25729399, Free PMC Article
    5. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. Nishikimi A, et al. FEBS Lett, 2005 Feb 14. PMID 15710388

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in marginal zone B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419911.1 → NP_001406840.1  dedicator of cytokinesis protein 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZZI3, A0A8I6AIC2
      Related
      ENSRNOP00000092846.2, ENSRNOT00000083988.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      89291936..89549871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084669.2 → XP_038940597.1  dedicator of cytokinesis protein 10 isoform X15

      UniProtKB/TrEMBL
      A0A8I6G204, A6JW89
      Related
      ENSRNOP00000078585.2, ENSRNOT00000091881.3
      Conserved Domains (4) summary
      cd08697
      Location:670 → 859
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1695 → 2140
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:181 → 301
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:44 → 154
      DUF3398; Domain of unknown function (DUF3398)

    2. XM_063267006.1 → XP_063123076.1  dedicator of cytokinesis protein 10 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNM2

    3. XM_008767315.4 → XP_008765537.2  dedicator of cytokinesis protein 10 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ADN8, A6JW89
      Related
      ENSRNOP00000091418.2, ENSRNOT00000093635.3
      Conserved Domains (4) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2154
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    4. XM_063267004.1 → XP_063123074.1  dedicator of cytokinesis protein 10 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNM2
      Related
      ENSRNOP00000100733.1, ENSRNOT00000146548.1

    5. XM_063267010.1 → XP_063123080.1  dedicator of cytokinesis protein 10 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    6. XM_063267003.1 → XP_063123073.1  dedicator of cytokinesis protein 10 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNM2

    7. XM_063267002.1 → XP_063123072.1  dedicator of cytokinesis protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNM2

    8. XM_017596832.3 → XP_017452321.2  dedicator of cytokinesis protein 10 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZNM2
      Conserved Domains (4) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1709 → 2121
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    9. XM_063267001.1 → XP_063123071.1  dedicator of cytokinesis protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    10. XM_063267000.1 → XP_063123070.1  dedicator of cytokinesis protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    11. XM_008767311.3 → XP_008765533.2  dedicator of cytokinesis protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZI3
      Conserved Domains (4) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2154
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    12. XM_063267009.1 → XP_063123079.1  dedicator of cytokinesis protein 10 isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    13. XM_063267005.1 → XP_063123075.1  dedicator of cytokinesis protein 10 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    14. XM_063267008.1 → XP_063123078.1  dedicator of cytokinesis protein 10 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    15. XM_063267007.1 → XP_063123077.1  dedicator of cytokinesis protein 10 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZZI3

    16. XM_039084666.2 → XP_038940594.1  dedicator of cytokinesis protein 10 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZI3
      Conserved Domains (4) summary
      cd08697
      Location:658 → 847
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1683 → 2128
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:169 → 289
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:32 → 142
      DUF3398; Domain of unknown function (DUF3398)

    17. XM_039084671.2 → XP_038940599.1  dedicator of cytokinesis protein 10 isoform X17

      Conserved Domains (3) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein Strain
    Heading Accession and Version

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