Ilf3 interleukin enhancer binding factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ilf3provided by RGD
Official Full Name: interleukin enhancer binding factor 3provided by RGD
Primary source: RGD:619734
See related: EnsemblRapid:ENSRNOG00000022741 AllianceGenome:RGD:619734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enzyme binding activity. Acts upstream of or within protein methylation. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human ILF3 (interleukin enhancer binding factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 115.1), Testes (RPKM 100.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28198454..28236634)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19922409..19960495)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22402877..22440984)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension.
Title: The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension.
Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway.
Title: Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway.
ILF3 protein inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide. Its expression is regulated by angiotensin II.
Title: Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:479168 (e-PCR)
- UniSTS:479168

Ilf3 (e-PCR), detects polymorphism
- UniSTS:479168

Ilf3 (e-PCR), detects polymorphism
- UniSTS:143585

MARC_21355-21356:1023203034:1 (e-PCR)
- UniSTS:268539

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosome-depend formation of circular RNA	IEA Inferred from Electronic Annotation more info
involved_in spliceosome-depend formation of circular RNA	ISO Inferred from Sequence Orthology more info
involved_in spliceosome-depend formation of circular RNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interleukin enhancer-binding factor 3

Names: M phase phosphoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053412.2 → NP_445864.2 interleukin enhancer-binding factor 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A6JNR5

Conserved Domains (3) summary

smart00572
Location:101 → 355

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:411 → 483

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:533 → 604

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28198454..28236634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266245.1 → XP_063122315.1 interleukin enhancer-binding factor 3 isoform X9

UniProtKB/Swiss-Prot

Q9JIL3
XM_008765994.4 → XP_008764216.1 interleukin enhancer-binding factor 3 isoform X6

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K4U6

Related

ENSRNOP00000073179.2, ENSRNOT00000085320.3

Conserved Domains (3) summary

smart00572
Location:88 → 342

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:398 → 470

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:520 → 591

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_063266244.1 → XP_063122314.1 interleukin enhancer-binding factor 3 isoform X7

UniProtKB/Swiss-Prot

Q9JIL3
XM_063266249.1 → XP_063122319.1 interleukin enhancer-binding factor 3 isoform X14

UniProtKB/TrEMBL

A0A8I6A0Y6
XM_063266252.1 → XP_063122322.1 interleukin enhancer-binding factor 3 isoform X15
XM_008765990.4 → XP_008764212.1 interleukin enhancer-binding factor 3 isoform X1

UniProtKB/Swiss-Prot

Q9JIL3

Conserved Domains (3) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:416 → 488

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:538 → 609

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_039082213.2 → XP_038938141.1 interleukin enhancer-binding factor 3 isoform X8

UniProtKB/Swiss-Prot

Q9JIL3

Conserved Domains (3) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:416 → 488

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:538 → 609

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_008765991.4 → XP_008764213.1 interleukin enhancer-binding factor 3 isoform X2

UniProtKB/Swiss-Prot

Q9JIL3

Conserved Domains (2) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

smart00358
Location:420 → 484

DSRM; Double-stranded RNA binding motif
XM_008765995.4 → XP_008764217.1 interleukin enhancer-binding factor 3 isoform X10

Conserved Domains (2) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

smart00358
Location:420 → 484

DSRM; Double-stranded RNA binding motif
XM_008765992.4 → XP_008764214.1 interleukin enhancer-binding factor 3 isoform X3

See identical proteins and their annotated locations for XP_008764214.1

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A6JNR5

Conserved Domains (3) summary

smart00572
Location:101 → 355

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:411 → 483

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:533 → 604

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_063266239.1 → XP_063122309.1 interleukin enhancer-binding factor 3 isoform X4

UniProtKB/Swiss-Prot

Q9JIL3
XM_008765993.4 → XP_008764215.1 interleukin enhancer-binding factor 3 isoform X5

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K2T6

Related

ENSRNOP00000072369.3, ENSRNOT00000079230.3

Conserved Domains (3) summary

smart00572
Location:93 → 347

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:403 → 475

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:525 → 596

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_008765996.4 → XP_008764218.1 interleukin enhancer-binding factor 3 isoform X12

UniProtKB/TrEMBL

F1LRU1

Related

ENSRNOP00000086301.2, ENSRNOT00000101953.2

Conserved Domains (2) summary

smart00572
Location:101 → 355

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

smart00358
Location:415 → 479

DSRM; Double-stranded RNA binding motif
XM_063266247.1 → XP_063122317.1 interleukin enhancer-binding factor 3 isoform X13
XM_063266242.1 → XP_063122312.1 interleukin enhancer-binding factor 3 isoform X6

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K4U6
XM_017595942.3 → XP_017451431.1 interleukin enhancer-binding factor 3 isoform X1

UniProtKB/Swiss-Prot

Q9JIL3

Conserved Domains (3) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:416 → 488

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:538 → 609

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_063266238.1 → XP_063122308.1 interleukin enhancer-binding factor 3 isoform X3

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A6JNR5
XM_039082212.2 → XP_038938140.1 interleukin enhancer-binding factor 3 isoform X6

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K4U6

Conserved Domains (3) summary

smart00572
Location:88 → 342

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:398 → 470

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:520 → 591

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_063266250.1 → XP_063122320.1 interleukin enhancer-binding factor 3 isoform X14

UniProtKB/TrEMBL

A0A8I6A0Y6
XM_063266248.1 → XP_063122318.1 interleukin enhancer-binding factor 3 isoform X13
XM_063266241.1 → XP_063122311.1 interleukin enhancer-binding factor 3 isoform X6

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K4U6
XM_039082210.2 → XP_038938138.1 interleukin enhancer-binding factor 3 isoform X1

UniProtKB/Swiss-Prot

Q9JIL3

Conserved Domains (3) summary

smart00572
Location:106 → 360

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

cd19910
Location:416 → 488

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:538 → 609

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
XM_063266240.1 → XP_063122310.1 interleukin enhancer-binding factor 3 isoform X5

UniProtKB/Swiss-Prot

Q9JIL3

UniProtKB/TrEMBL

A0A0G2K2T6
XM_063266246.1 → XP_063122316.1 interleukin enhancer-binding factor 3 isoform X11

UniProtKB/Swiss-Prot

Q9JIL3
XM_039082216.2 → XP_038938144.1 interleukin enhancer-binding factor 3 isoform X16

Conserved Domains (2) summary

cd19910
Location:63 → 135

DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

cd19912
Location:185 → 256

DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins