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    Cdon cell adhesion associated, oncogene regulated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50938, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cdonprovided by RGD
    Official Full Name
    cell adhesion associated, oncogene regulatedprovided by RGD
    Primary source
    RGD:708433
    See related
    EnsemblRapid:ENSRNOG00000011789 AllianceGenome:RGD:708433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdo
    Summary
    Involved in cell adhesion. Acts upstream of or within smoothened signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 58.7), Lung (RPKM 50.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdon in Genome Data Viewer
    Location:
    8q21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (42032921..42119451)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (33775123..33861635)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (36625757..36712091)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 118, member B Neighboring gene RNA pseudouridine synthase D4 Neighboring gene cell adhesion associated, oncogene regulated like 1 Neighboring gene uncharacterized LOC102548010 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene enolase 1, pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic body morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic retina morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lens development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle satellite cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle satellite cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell adhesion molecule-related/down-regulated by oncogenes
    Names
    Cdon homolog
    immunoglobulin superfamily member

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017358.3NP_059054.2  cell adhesion molecule-related/down-regulated by oncogenes precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O35158
      UniProtKB/TrEMBL
      A6JYK5, G3V7K7
      Conserved Domains (6) summary
      smart00408
      Location:236294
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:718808
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:588663
      fn3; Fibronectin type III domain
      pfam07679
      Location:405517
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28113
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      42032921..42119451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242791.5XP_006242853.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

      Related
      ENSRNOP00000016247.1, ENSRNOT00000016248.6
      Conserved Domains (6) summary
      smart00408
      Location:236294
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:718808
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:588663
      fn3; Fibronectin type III domain
      pfam07679
      Location:405517
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    2. XM_006242793.5XP_006242855.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

      UniProtKB/Swiss-Prot
      O35158
      UniProtKB/TrEMBL
      A0A8I6A2E2
      Related
      ENSRNOP00000085481.1, ENSRNOT00000103041.2
      Conserved Domains (5) summary
      smart00408
      Location:326387
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:227306
      IG_like; Immunoglobulin like
      cd00063
      Location:600690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:313397
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:33113
      Ig; Immunoglobulin domain
    3. XM_006242792.5XP_006242854.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

      See identical proteins and their annotated locations for XP_006242854.1

      UniProtKB/Swiss-Prot
      O35158
      UniProtKB/TrEMBL
      A6JYK5, G3V7K7
      Conserved Domains (6) summary
      smart00408
      Location:236294
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:718808
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:588663
      fn3; Fibronectin type III domain
      pfam07679
      Location:405517
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    4. XM_063266036.1XP_063122106.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

      UniProtKB/TrEMBL
      A6JYK5, G3V7K7
    5. XM_039082008.2XP_038937936.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

      UniProtKB/Swiss-Prot
      O35158
      UniProtKB/TrEMBL
      A6JYK5, G3V7K7
      Conserved Domains (6) summary
      smart00408
      Location:236294
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:718808
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:588663
      fn3; Fibronectin type III domain
      pfam07679
      Location:405517
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28113
      Ig; Immunoglobulin domain

    RNA

    1. XR_005487905.2 RNA Sequence