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    Nmnat3 nicotinamide nucleotide adenylyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmnat3provided by RGD
    Official Full Name
    nicotinamide nucleotide adenylyltransferase 3provided by RGD
    Primary source
    RGD:1309140
    See related
    EnsemblRapid:ENSRNOG00000013585 AllianceGenome:RGD:1309140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. Involved in response to tumor necrosis factor. Located in axon and neuronal cell body. Used to study glaucoma. Orthologous to human NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 86.9), Spleen (RPKM 81.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmnat3 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107771124..107888528)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (98892168..99003912)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106317038..106429535)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene calsyntenin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene retinol binding protein 1 Neighboring gene retinol binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration. Kitaoka Y, et al. Cell Death Dis, 2013 Oct 17. PMID 24136224, Free PMC Article
    2. NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy. Yue Z, et al. Exp Cell Res, 2016 Oct 1. PMID 27423420
    3. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. Sasaki Y, et al. J Neurosci, 2006 Aug 16. PMID 16914673, Free PMC Article
    4. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. Berger F, et al. J Biol Chem, 2005 Oct 28. PMID 16118205
    5. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, et al. Endocr Rev, 2010 Apr. PMID 20007326, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD.
      Title: NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
    2. These results suggest that the axonal-protective effect of Nmnat3 may be involved in autophagy machinery.
      Title: Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
    Names
    nicotinamide mononucleotide adenylyltransferase 3
    NP_001382630.1
    NP_001382631.1
    XP_038937700.1
    XP_038937702.1
    XP_038937703.1
    XP_063121871.1
    XP_063121872.1
    XP_063121873.1
    XP_063121874.1
    XP_063121875.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395701.1 → NP_001382630.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2B1, F7F588
      Conserved Domains (1) summary
      cd09286
      Location:7 → 232
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    2. NM_001395702.1 → NP_001382631.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2B1, F7F588
      Related
      ENSRNOP00000018411.5, ENSRNOT00000018411.8
      Conserved Domains (1) summary
      cd09286
      Location:7 → 232
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      107771124..107888528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081775.2 → XP_038937703.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X6

      Conserved Domains (1) summary
      cl00015
      Location:26 → 117
      nt_trans; nucleotidyl transferase superfamily

    2. XM_039081772.2 → XP_038937700.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X3

      Conserved Domains (1) summary
      cl00015
      Location:26 → 163
      nt_trans; nucleotidyl transferase superfamily

    3. XM_063265801.1 → XP_063121871.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A6I2B1, F7F588

    4. XM_063265802.1 → XP_063121872.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      A6I2B1, F7F588

    5. XM_063265805.1 → XP_063121875.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X7

    6. XM_063265804.1 → XP_063121874.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X4

    7. XM_063265803.1 → XP_063121873.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNV6

    8. XM_039081774.2 → XP_038937702.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X5

      Conserved Domains (1) summary
      cl00015
      Location:17 → 122
      nt_trans; nucleotidyl transferase superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013224.2: Suppressed sequence

      Description
      NM_001013224.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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