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    Gramd1b GRAM domain containing 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300644, updated on 27-Nov-2024

    Summary

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    Symbol
    Gramd1bprovided by RGD
    Full Name
    GRAM domain containing 1Bprovided by RGD
    Primary source
    RGD:1305443
    See related
    EnsemblRapid:ENSRNOG00000053577 AllianceGenome:RGD:1305443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305443
    Summary
    Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1B (GRAM domain containing 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 464.1), Kidney (RPKM 85.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gramd1b in Genome Data Viewer
    Location:
    8q22
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (49551642..49790965, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (40654492..40893869, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (44160634..44399110, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094120 Neighboring gene zinc finger protein 202 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene uncharacterized LOC134480034 Neighboring gene uncharacterized LOC134480035 Neighboring gene uncharacterized LOC134480138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Aster-B
    Names
    GRAM domain-containing protein 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191616.1 → NP_001178545.1  protein Aster-B

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZLB1
      Related
      ENSRNOP00000110666.1, ENSRNOT00000172877.1
      Conserved Domains (2) summary
      cd13220
      Location:251 → 344
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:519 → 663
      DUF4782; Domain of unknown function (DUF4782)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      49551642..49790965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265091.1 → XP_063121161.1  protein Aster-B isoform X9

      UniProtKB/TrEMBL
      A0A8I6A3S5
      Related
      ENSRNOP00000086431.1, ENSRNOT00000098747.2

    2. XM_063265090.1 → XP_063121160.1  protein Aster-B isoform X8

      Related
      ENSRNOP00000084513.2, ENSRNOT00000119190.2

    3. XM_063265084.1 → XP_063121154.1  protein Aster-B isoform X1

    4. XM_063265086.1 → XP_063121156.1  protein Aster-B isoform X4

    5. XM_039081030.2 → XP_038936958.1  protein Aster-B isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLB1, A0A8I6A887
      Related
      ENSRNOP00000088511.1, ENSRNOT00000099621.2
      Conserved Domains (2) summary
      cd13220
      Location:250 → 343
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:518 → 666
      DUF4782; Domain of unknown function (DUF4782)

    6. XM_063265085.1 → XP_063121155.1  protein Aster-B isoform X2

    7. XM_063265089.1 → XP_063121159.1  protein Aster-B isoform X7

    8. XM_063265099.1 → XP_063121169.1  protein Aster-B isoform X6

    9. XM_063265088.1 → XP_063121158.1  protein Aster-B isoform X6

      Related
      ENSRNOP00000094998.2, ENSRNOT00000097795.2

    10. XM_063265098.1 → XP_063121168.1  protein Aster-B isoform X6

    11. XM_063265092.1 → XP_063121162.1  protein Aster-B isoform X10

      UniProtKB/TrEMBL
      A0A8I6AAR1
      Related
      ENSRNOP00000093680.2, ENSRNOT00000107338.2

    12. XM_063265093.1 → XP_063121163.1  protein Aster-B isoform X11

    13. XM_063265094.1 → XP_063121164.1  protein Aster-B isoform X6

    14. XM_063265095.1 → XP_063121165.1  protein Aster-B isoform X6

    15. XM_063265097.1 → XP_063121167.1  protein Aster-B isoform X6

    16. XM_063265096.1 → XP_063121166.1  protein Aster-B isoform X6

    17. XM_039081042.2 → XP_038936970.1  protein Aster-B isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZZR8, A0A8I6GLE8
      Conserved Domains (2) summary
      cd13220
      Location:71 → 164
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:339 → 487
      DUF4782; Domain of unknown function (DUF4782)

    18. XM_063265087.1 → XP_063121157.1  protein Aster-B isoform X5

    19. XM_063265100.1 → XP_063121170.1  protein Aster-B isoform X13

    20. XM_063265101.1 → XP_063121171.1  protein Aster-B isoform X14

    RNA

    1. XR_010053942.1 RNA Sequence

    2. XR_010053943.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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